Adipose tissue coregulates cognitive function
Oliveras-Cañellas, Núria (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Castells-Nobau, Anna (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
de la Vega-Correa, Lisset (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Latorre-Luque, Jessica (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Motger Albertí, Anna (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Arnoriaga-Rodriguez, Maria (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Garre-Olmo, Josep (Universitat de Girona)
Zapata-Tona, Cristina (Institut d'Investigació Biomèdica de Girona)
Coll-Martínez, Clàudia (Universitat de Girona)
Ramió-Torrentà, Lluís (Institut d'Investigació Biomèdica de Girona)
Moreno-Navarrete, José Maria (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Puig, Josep (Universitat de Girona)
Villarroya, Francesc (Universitat de Barcelona. Center for Biomedical Research Network)
Ramos, Rafel (Universitat de Girona. Institut Universitari per a la Recerca en Atenció Primària Jordi Gol I Gorina)
Casadó-Anguera, Verònica (Universitat Pompeu Fabra. Parc Salut Mar. Laboratory of Neuropharmacology-Neurophar)
Martín-García, Elena 1975- (Universitat Pompeu Fabra. Parc Salut Mar. Laboratory of Neuropharmacology-Neurophar)
Maldonado, Rafael 1961- (Universitat Pompeu Fabra)
Mayneris-Perxachs, Jordi (Universitat de Girona. Girona Biomedical Research Institute. Center for Biomedical Research Network)
Fernández-Real, José Manuel (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)

Date:	2023
Abstract:	Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT in three cohorts that were associated with performance in different cognitive domains. These genes were mostly involved in synaptic function, phosphatidylinositol metabolism, the complement cascade, anti-inflammatory signaling, and vitamin metabolism. These findings were translated into the plasma metabolome. The circulating blood expression levels of most of these genes were also associated with several cognitive domains in a cohort of 816 participants. Targeted misexpression of candidate gene ortholog in the Drosophila fat body significantly altered flies memory and learning. Among them, down-regulation of the neurotransmitter release cycle-associated gene SLC18A2 improved cognitive abilities in Drosophila and in mice. Up-regulation of RIMS1 in Drosophila fat body enhanced cognitive abilities. Current results show previously unidentified connections between AT transcriptome and brain function in humans, providing unprecedented diagnostic/therapeutic targets in AT.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	SDG 3 - Good Health and Well-being
Published in:	Science advances, Vol. 9 Núm. 32 (2023) , p. eadg4017, ISSN 2375-2548

DOI: 10.1126/sciadv.adg4017
PMID: 37566655

21 p, 2.7 MB

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