Home > Articles > Published articles > Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents |
Date: | 2023 |
Abstract: | Titanium dioxide nanoparticles (TiO NPs) are one of the main sources of the nanoparticulate matter exposure to humans. Although several studies have demonstrated their potential toxic effects, the real nature of the correlation between NP properties and their interaction with biological targets is still far from being fully elucidated. Here, engineered TiO NPs with various geometries (bipyramids, plates, and rods) have been prepared, characterized and intravenously administered in healthy mice. Parameters such as biodistribution, accumulation, and toxicity have been assessed in the lungs and liver. Our data show that the organ accumulation of TiO NPs, measured by ICP-MS, is quite low, and this is only partially and transiently affected by the NP geometries. The long-lasting permanence is exclusively restricted to the lungs. Here, bipyramids and plates show a higher accumulation, and interestingly, rod-shaped NPs are the most toxic, leading to histopathological pulmonary alterations. In addition, they are also able to induce a transient increase in serum markers related to hepatocellular injury. These results indicate that rods, more than bipyramidal and spherical geometries, lead to a stronger and more severe biological effect. Overall, small physico-chemical differences can dramatically modify both accumulation and safety. |
Grants: | Agencia Estatal de Investigación PID2019-111218RB-I00 Agencia Estatal de Investigación RYC-2017-23457 Ministerio de Ciencia, Innovación y Universidades RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Titanium dioxide nanomaterial ; Physico-chemical properties ; Biodistribution ; Nanotoxicity |
Published in: | Nanomaterials, Vol. 13, Issue 7 (April 2023) , art. 1174, ISSN 2079-4991 |
19 p, 9.0 MB |