Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes : two independent parameters that explore different neuronal circuits
Ortiz-Zúñiga, Ángel Michael ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rojano-Toimil, Alba ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Rahnama Zand, Kimia ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Lainez, Elena ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Raguer, Nuria ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron)
Simó-Servat, Olga ![Identificador ORCID](/img/uab/orcid.ico)
(Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Cristina
(Hospital Universitari Vall d'Hebron. Institut de Recerca)
Simó Canonge, Rafael
(Hospital Universitari Vall d'Hebron)
Ciudin, Andreea
(Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona
Fecha: |
2023 |
Resumen: |
Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway. Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75-100 uV) were analyzed. Thirty three patients (45% women, 72. 1 ± 4. 6 years) were included. VEP parameters significantly correlated with RS but not with GF. These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment. |
Ayudas: |
Instituto de Salud Carlos III PI20/01703
|
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Retinal microperimetry ;
Retinal sensitivity ;
Gaze fixation ;
Type 2 diabetes ;
Visual evoked potentials |
Publicado en: |
Journal of endocrinological investigation, Vol. 46 (march 2023) , p. 1875-1880, ISSN 1720-8386 |
DOI: 10.1007/s40618-023-02046-y
PMID: 36870015
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