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Página principal > Artículos > Artículos publicados > Industrial By-Products As a Novel Circular Source of Biocompatible Extracellular Vesicles |
Fecha: | 2022 |
Resumen: | Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. This study explores and defines the use of food industry by-products (BP) as a circular source of safe biocompatible EVs. Averaged diameter and molecular compositions indicate a large yield of exosomes and high abundancy of membrane lipids with signaling capacity in these vesicles. Complex proteomes mimicking those circulating in human blood plasma are also identified. Furthermore, BP-EVs do not show relevant cytotoxicity and display excellent oral and intravenous bioavailability together with specific organ targeting capacity. Collectively, it is believed that the novel findings reported here will open substantial venues for the use of BP as an optimal source of biocompatible nanovesicles in manifold applications of the biotechnological and biomedical fields. |
Ayudas: | Ministerio de Ciencia e Innovación PID2020-114885RB-C21 Instituto de Salud Carlos III PI20/00623 Instituto de Salud Carlos III CD19/00243 Instituto de Salud Carlos III CP21/00096 Instituto de Salud Carlos III CPII20/00007 |
Nota: | Altres ajuts: Research and Education Council of the Community of Madrid (2018-T1/BIO-10633); Talento Program 2018, Community of Madrid; European Union Funds; European Social (PEJD-2019-PRE/BIO-16475); CERCA Program, Generalitat de Catalunya. |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Publicado en: | Advanced functional materials, Vol. 32 Núm. 29 (july 2022) , p. 2202700, ISSN 1616-3028 |
14 p, 7.2 MB |