Trace cisplatin and carboplatin removal by 3-mercaptopropionic acid and L-cysteine functionalized sponges : Adsorption behaviour and mechanism
Han, Dong (Universitat Autònoma de Barcelona. Departament de Química)
López-Mesas, Montserrat (Universitat Autònoma de Barcelona. Departament de Química)
Boada, Roberto (Universitat Autònoma de Barcelona. Departament de Química)
Farías, Tania (University of Havana. Institute of Materials Science and Technology)
Lazo Fraga, Ana R. (University of Havana. Institute of Materials Science and Technology)
Valiente Malmagro, Manuel (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2023
Resum:	This study presents functionalized open-celled cellulose Metalzorb® sponge (Sponge) with 3-mercaptopropionic acid (MPA) and L-Cysteine (Cys), and the resulting MPA@Sponge and Cys@Sponge showed significantly improved removal efficiency towards trace cisplatin and carboplatin against Sponge. MPA@Sponge achieved maximum removal of 88. 9 ± 0. 5% for cisplatin and 85. 2 ± 0. 4% for carboplatin, while Cys@Sponge achieved maximum removal of 75 ± 2% and 59 ± 1%. In contrast, Sponge only achieved removal of 29 ± 4% and 4 ± 1%, respectively. It suggests that thiol groups serve as favourable binding sites for Pt complexation. Carboplatin exhibits lower adsorption compared to cisplatin due to its limited hydration. However, the presence of Cl in stock and high temperature facilitate the hydration and the formation of active derivatives of carboplatin, thereby enhancing its adsorption. The rapid adsorption processes of cisplatin and carboplatin are well described by the pseudo-second-order kinetic model involving diffusion and chemisorption. The results from adsorption isotherms revealed a monolayer adsorption that aligns with the principles proposed by the Langmuir model. High temperature significantly enhances the adsorption, and the positive enthalpies indicate that the binding of Pt with thiol groups is endothermic process. X-ray absorption spectroscopy measurements at the Pt L-edge revealed a similar coordination environment of the adsorbed Pt on both functionalized adsorbents, which can be attributed to the formation of four Pt-S bonds during the adsorption. To assess the validity of the adsorption results under realistic medium conditions, an adsorption study was carried out by using diluted urine spiked with trace platinum cytostatic drugs to simulate hospital wastewater. 90. 2 ± 0. 3% of cisplatin and 77. 0 ± 0. 2% of carboplatin was effectively removed by MPA@Sponge from diluted urine.
Ajuts:	European Commission 778266
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adsorption ; Cisplatin ; Carboplatin ; Pt-based cytostatics ; Thiol-functionalization ; XAS
Publicat a:	Chemical engineering journal, Vol. 472 (September 2023) , art. 144894, ISSN 1873-3212

DOI: 10.1016/j.cej.2023.144894

13 p, 5.7 MB

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