Nanoceria as Safe Contrast Agents for X-ray CT Imaging
García Sanz, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cámara, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Boullosa, Ana María (Networking Research Centre on Bioengineering)
Gustà, Muriel F. (Institut Català de Nanociència i Nanotecnologia)
Mondragón, Laura (Institut Català de Nanociència i Nanotecnologia)
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Casals, Eudald (Wuyi University)
Abasolo, Ibane (Hospital Universitari Vall d'Hebron)
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)

Date:	2023
Abstract:	Cerium oxide nanoparticles (CeONPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce atom's high Z number makes it an ideal candidate for utilisation as an X-ray imaging contrast agent. We herein show how the injection of albumin-stabilised 5 nm CeONPs into mice revealed substantial enhancement in X-ray contrast, reaching up to a tenfold increase at significantly lower concentrations than commercial or other proposed contrast agents. Remarkably, these NPs exhibited prolonged residence time within the target organs. Thus, upon injection into the tail vein, they exhibited efficient uptake by the liver and spleen, with 85% of the injected dose (%ID) recovered after 7 days. In the case of intratumoral administration, 99% ID of CeONPs remained within the tumour throughout the 7-day observation period, allowing for observation of disease dynamics. Mass spectrometry (ICP-MS) elemental analysis confirmed X-ray CT imaging observations.
Grants:	Agencia Estatal de Investigación RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1431 Ministerio de Economía y Competitividad SEV-2017-0706
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Nanoceria ; CeO nanoparticles ; X-ray CT imaging ; Reactive oxygen species scavengers
Published in:	Nanomaterials, Vol. 13, Issue 15 (August 2023) , art. 2208, ISSN 2079-4991

DOI: 10.3390/nano13152208
PMID: 37570527

13 p, 1.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles