Current challenges in chronic bronchial infection in patients with chronic obstructive pulmonary disease
Lopez-Campos, José Luis (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau)
Cantón, Rafael (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid))
Soler-Cataluña, Juan Jose (Hospital Arnau de Villanova-Lliria)
Martinez-Garcia, Miguel Angel (Hospital Universitari i Politècnic La Fe (València))
Universitat Autònoma de Barcelona

Fecha:	2020
Resumen:	Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chronic bronchial infection ; COPD ; Potentially pathogenic microorganism
Publicado en:	Journal of clinical medicine, Vol. 9 Núm. 6 (june 2020) , p. 1639, ISSN 2077-0383

DOI: 10.3390/jcm9061639
PMID: 32481769

19 p, 779.0 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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