Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years : A systemic review
Mourino, Nerea (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública)
Ruano-Raviña, Alberto (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Varela Lema, Leonor (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública)
Fernández, Esteve (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
López Medina, María José (Institut d'Investigació Biomèdica Sant Pau)
Santiago-Pérez, María Isolina (Dirección General de Salud Pública de Galicia. Unidad de Epidemiología)
Rey-Brandariz, Julia (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública)
Giraldo-Osorio, Alexandra (Fundación Carolina)
Pérez-Ríos, Mónica (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)

Fecha:	2022
Resumen:	Background Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS. Methods A systematic review performed in the Pubmed (MEDLINE) and EMBASE databases up to April 2021 was conducted using as key words "serum cotinine", "tobacco smoke pollution" (MeSH), "secondhand smoke", "environmental tobacco smoke" and "tobacco smoke exposure". Papers which assessed SHS exposure among children younger than 5 years old were included. The PRISMA 2020 guidelines were followed. Analysis was pre-registered in PROSPERO (registration number: CRD42021251263). Results 247 articles were identified and 51 fulfilled inclusion criteria. The selected studies were published between 1985-2020. Most of them included adolescents and adults. Only three assessed postnatal exposure exclusively among children under 5 years. None of the selected studies proposed age-specific cut-points for children < 5 years old. Cut-point values to assess SHS exposure ranged from 0. 015 to 100 ng/ml. The most commonly used cut-point was 0. 05 ng/ml, derived from the assay limit of detection used by the National Health and Nutrition Examination Survey (NHANES). Conclusions No studies have calculated serum cotinine age-specific cut-points to ascertained SHS exposure among children under 5 years old. Children's age-specific cut-points are warranted for health research and public health purposes aimed at accurately estimating the prevalence of SHS exposure and attributable burden of disease to such exposure, and at reinforcing 100% smoke-free policies worldwide, both in homes, private vehicles and public places.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; recerca ; Versió publicada
Materia:	Adolescent ; Adult ; Child ; Child, Preschool ; Cotinine ; Environmental Exposure ; Humans ; Nutrition Surveys ; Prevalence ; Smoke-Free Policy ; Tobacco Smoke Pollution
Publicado en:	PloS one, Vol. 17 Núm. 5 May (may 2022) , p. e0267319, ISSN 1932-6203

DOI: 10.1371/journal.pone.0267319
PMID: 35511766

17 p, 834.1 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados