Standardization of canine meningioma grading : Validation of new guidelines for reproducible histopathologic criteria
Belluco, Sara (Université de Lyon)
Marano, G. (University of Milan. Department of Biomedical and Clinical Sciences "L. Sacco")
Lurier, T. (Université de Lyon)
Avallone, Giancarlo (Università di Bologna. Dipartimento di Scienze Mediche Veterinarie)
Brachelente, C. (Università degli Studi di Perugia. Dipartimento di Medicina Veterinaria)
Di Palma, S. (IDEXX Laboratories)
Rasotto, R. (Dick White Referrals. Station Farm)
Baiker, K. (University of Hong Kong. Department of Veterinary Clinical Sciences)
Beineke, Andreas (Stiftung Tierärztliche Hochschule Hannover)
Oevermann, A. (University of Bern. Division of Neurological Sciences)
Seehusen, F. (University of Zurich. Institute of Veterinary Pathology)
Sant'Ana, Fabiano (Universidade de Brasília. Laboratório de Diagnóstico Patológico Veterinário)
Boracchi, Patrizia (University of Milan. Department of Biomedical and Clinical Sciences "L. Sacco")
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Mandara, M.T. (Università degli Studi di Perugia)

Data:	2023
Resum:	Canine meningiomas are currently graded using the human grading system. Recently published guidelines have adapted the human grading system for use in dogs. The goal of this study was to validate the new guidelines for canine meningiomas. To evaluate the inter-observer agreement, 5 veterinary surgical pathologists graded 158 canine meningiomas following the human grading system alone or with the new guidelines. The inter-observer agreement for histologic grade and each of the grading criteria (mitotic grade, invasion, spontaneous necrosis, macronucleoli, small cells, hypercellularity, pattern loss and anaplasia) was evaluated using the Fleiss kappa index. The diagnostic accuracy (sensitivity and specificity) was assessed by comparing the diagnoses obtained with the 2 grading systems with a consensus grade (considered the reference classification). The consensus histologic grade was obtained by agreement between 4 experienced veterinary neuropathologists following the guidelines. Compared with the human grading alone, the canine-specific guidelines increased the inter-observer agreement for: histologic grade (κ = 0. 52); invasion (κ = 0. 67); necrosis (κ = 0. 62); small cells (κ = 0. 36); pattern loss (κ = 0. 49) and anaplasia (κ = 0. 55). Mitotic grade agreement remained substantial (κ = 0. 63). The guidelines improved the sensitivity in identifying grade 1 (95. 6%) and the specificity in identifying grade 2 (96. 2%) meningiomas. In conclusion, the new grading guidelines for canine meningiomas are associated with an overall improvement in the inter-observer agreement and higher diagnostic accuracy in diagnosing grade 1 and grade 2 meningiomas.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Central nervous system ; Dog ; Grading ; Meningioma ; Standardization
Publicat a:	Veterinary and Comparative Oncology, Vol. 21 Núm. 4 (december 2023) , p. 685-699, ISSN 1476-5829

DOI: 10.1111/vco.12932

15 p, 7.2 MB

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