Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer
Muñoz Martin, Andrés (Hospital General Universitario Gregorio Marañón)
Ortega, Israel (Gendiag)
Font, C (Hospital Clínic i Provincial de Barcelona)
Pachón, Vanessa (Hospital Universitario Ramón y Cajal (Madrid))
Castellón, Victoria (Complejo Hospitalario Torrecárdenas (Almeria))
Martínez-Marín, Virginia (Hospital Universitario La Paz (Madrid))
Salgado, Mercedes (Complexo Hospitalario Universitario de Ourense - CHUO)
Martínez, Eva (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Calzas, Julia (Hospital Universitario de Fuenlabrada ( Madrid))
Rupérez, Ana (Hospital Universitario Fundación Jiménez Díaz)
Souto, Juan Carlos (Institut d'Investigació Biomèdica Sant Pau)
Martín, Miguel (Hospital General Universitario Gregorio Marañón)
Salas, Eduardo (Gendiag)
Soria Fernández, José Manuel (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Fecha:	2018
Resumen:	Venous thromboembolism (VTE) is a leading cause of death among patients with cancer. Outpatients with cancer should be periodically assessed for VTE risk, for which the Khorana score is commonly recommended. However, it has been questioned whether this tool is sufficiently accurate at identifying patients who should receive thromboprophylaxis. The present work proposes a new index, TiC-Onco risk score to be calculated at the time of diagnosis of cancer, that examines patients' clinical and genetic risk factors for thrombosis. We included 391 outpatients with a recent diagnosis of cancer and candidates for systemic outpatient chemotherapy. All were treated according to standard guidelines. The study population was monitored for 6 months, and VTEs were recorded. The Khorana and the TiC-Onco scores were calculated for each patient and their VTE predictive accuracy VTEs was compared. We recorded 71 VTEs. The TiC-Onco risk score was significantly better at predicting VTE than the Khorana score (AUC 0. 73 vs. 0. 58, sensitivity 49 vs. 22%, specificity 81 vs. 82%, PPV 37 vs. 22%, and NPV 88 vs. 82%). TiC-Onco risk score performed significantly better than Khorana score at identifying cancer patients at high risk of VTE who would benefit from personalised thromboprophylaxis.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Contribució a congrés ; recerca ; Versió publicada
Materia:	Genetic testing ; Predictive markers
Publicado en:	British journal of cancer, Vol. 118 Núm. 8 (january 2018) , p. 1056-1061, ISSN 1532-1827

DOI: 10.1038/s41416-018-0027-8
PMID: 29588512

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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