Covalent and non-covalent binding in vanadium-protein adducts
Ugone, Valeria (Istituto CNR di Chimica Biomolecolare)
Sanna, Daniele (Istituto CNR di Chimica Biomolecolare)
Ruggiu, Simone (Università di Sassari. Dipartimento di Chimica e Farmacia)
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya)
Garribba, Eugenio (Università di Sassari. Dipartimento di Chimica e Farmacia)

Fecha:	2021
Resumen:	The ESI-MS and EPR results obtained during the study of systems containing vanadium-protein adducts have been explained integrating the spectrometric and spectroscopic responses with molecular modelling simulations. The representative systems formed by the potential antibacterial drug [VIVO(nalidixato)2(H2O)] with lysozyme and cytochrome c were fully characterized, interpreting the ESI-MS and EPR signals as the result of covalent and non-covalent binding. This behaviour should be considered for all metal-protein systems, and instrumental techniques - if necessary - should be coupled with modelling to achieve full characterization of the types of binding.
Derechos:	Tots els drets reservats.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Publicado en:	Inorganic Chemistry Frontiers, Vol. 8, issue 5 (March 2021) , p. 1189-1196, ISSN 2052-1553

DOI: 10.1039/D0QI01308K

Postprint 8 p, 852.2 KB

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