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| Pàgina inicial > Articles > Articles publicats > The SOS response controls integron recombination |
(Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) (Centro Nacional de Microelectrónica (Espanya)) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)| Data: | 2009 |
| Resum: | Integrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies. |
| Ajuts: | European Commission 019023 European Commission 506122 Ministerio de Ciencia e Innovación GEN2006-27767-E/PAT Ministerio de Ciencia e Innovación BFU2008-01078/BMC Agència de Gestió d'Ajuts Universitaris i de Recerca 2005/SGR-533 |
| Drets: | Tots els drets reservats.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió acceptada per publicar |
| Publicat a: | Science, Vol. 324, issue 5930 (May 2009) , p. 1034, ISSN 1095-9203 |
6 p, 470.1 KB |
