A Series of Non-Oxido VIVComplexes of Dibasic ONS Donor Ligands : Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
Banerjee, Atanu (National Institute of Technology Rourkela)
Patra, Sushree Aradhana (National Institute of Technology Rourkela)
Sahu, Gurunath (National Institute of Technology Rourkela)
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya)
Pisanu, Federico (Università di Sassari)
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia)
Carvalho, M. Fernanda N.N. (Universidade de Lisboa)
Correia, Isabel (Universidade de Lisboa)
Costa Pessoa, João (Universidade de Lisboa)
Reuter, Hans (Osnabrück University)
Dinda, Rupam (National Institute of Technology Rourkela)

Data:	2023
Resum:	A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4, are reported. All the synthesized non-oxido VIVcompounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1-3 reveal that the mononuclear non-oxido VIVcomplexes show distorted octahedral (1 and 2) or trigonal prismatic (3) arrangement around the non-oxido VIVcenter. EPR and DFT data indicate the coexistence of mer and fac isomers in solution, and ESI-MS results suggest a partial oxidation of [VIV(L1-4)2] to [VV(L1-4)2]+and [VVO2(L1-4)]-therefore, all these three complexes are plausible active species. Complexes 1-4 interact with bovine serum albumin (BSA) with a moderate binding affinity, and docking calculations reveal non-covalent interactions with different regions of BSA, particularly with Tyr, Lys, Arg, and Thr residues. In vitro cytotoxic activity of all complexes is assayed against the HT-29 (colon cancer) and HeLa (cervical cancer) cells and compared with the NIH-3T3 (mouse embryonic fibroblast) normal cell line by MTT assay and DAPI staining. The results suggest that complexes 1-4 are cytotoxic in nature and induce cell death in the cancer cell lines by apoptosis and that a mixture of VIV, VV, and VVO2species could be responsible for the biological activity.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	SDG 3 - Good Health and Well-being
Publicat a:	Inorganic chemistry, Vol. 62, Issue 20 (May 2023) , p. 7932-7953, ISSN 1520-510X

DOI: 10.1021/acs.inorgchem.3c00753
PMID: 37154533

22 p, 10.5 MB

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