Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy
Vart, Priya (University Medical Center Groningen (Països Baixos))
Duivenvoorden, Raphaël (Radboud University Medical Center (Països Baixos))
Adema, Aaltje Y. (Medisch Centrum Leeuwarden (Països Baixos))
Covic, Adrian Constantin (Dr Ci Parhon Hospital (Romania))
Finne, Patrik (Helsinki University Central Hospital and Helsinki University (Finlàndia))
Braak, Nicole Heitink Ter (Zuyderland Ziekenhuis)
Laine, Kaisa (Satakunta Central Hospital (Finlàndia))
Noordzij, Marlies (University of Groningen (Països Baixos))
Schouten, Marcel (Tergooi Medical Center (Països Baixos))
Jager, Kitty (Amsterdam Public Health Research Institute (Països Baixos))
Gansevoort, Ron T. (University of Groningen (Països Baixos))
van der Net, Jeroen B. (Albert Schweitzer Hospital (Països Baixos))
Essig, Marie (APHP Paris-Saclay University (França))
du Buf-Vereijken, Peggy W. G. (Amphia Hospital (Breda, Països Baixos))
van Ginneken, Betty (Amphia Hospital (Breda, Països Baixos))
Maas, Nanda (Amphia Hospital (Breda, Països Baixos))
van Jaarsveld, Brigit (Amsterdam University Medical Center (UMC))
Bemelman, Fréderike José (Amsterdam University Medical Center (UMC))
Klingenberg-Salahova, Farah (Amsterdam University Medical Center (UMC))
Heenan-Vos, Frederiek (Amsterdam University Medical Center (UMC))
Vervloet, Marc (Amsterdam University Medical Center (UMC))
Nurmohamed, Azam S. (Amsterdam University Medical Center (UMC))
Vogt, Liffert (Amsterdam University Medical Center (UMC))
Abramowicz, Daniel (University Hospital Antwerp (Bèlgica))
Verhofstede, Sabine (University Hospital Antwerp (Bèlgica))
Maoujoud, Omar (Cadi Ayyad University (Marroc))
Malfait, Thomas L. A. (AZ Delta (Bèlgica))
Fialova, Jana (B. Braun Avitum (Repùblica Txeca))
Melilli, Edoardo (Hospital Universitari de Bellvitge)
Favà, Alexandre (Hospital Universitari de Bellvitge)
Cruzado, Josep María (Hospital Universitari de Bellvitge)
Perez, Nuria Montero (Hospital Universitari de Bellvitge)
Lips, Joy (Bernhoven Hospital (Països Baixos))
Krepel, Harmen P. (Bravis Hospital (Països Baixos))
Adilovic, Harun (Cantonal Hospital Zenica (Bòsnia i Hercegovina))
Radulescu, Daniela (Emergency Clinical Hospital 'Sf. Ioan' (Bucarest))
Hengst, Maaike (Catharina Hospital Eindhoven (Eindhoven, Països Baixos))
Konings, Constantijn J. A. M. (Catharina Hospital Eindhoven (Eindhoven, Països Baixos))
Rydzewski, Andrzej (Central Clinical Hospital of the Ministry of Interior (Polònia))
Braconnier, Philippe (Centre Hospitalier du Nord (Suïssa))
Weis, Daniel (Centre Hospitalier du Nord (Suïssa))
Gellert, Ryszard (Centre of Postgraduate Medical Education)
Oliveira, João (Centrodial (Outpatient Dialysis Center))
Alferes, Daniela G. (Centro Hospitalar Vila Nova de Gaia/Espinho (Portugal))
Zakharova, Elena (City Hospital N.a. S.P. Botkin (Rússia))
Ambühl, Patrice Max (City Hospital Zürich (Suïssa))
Guidotti, Rebecca (City Hospital Zürich (Suïssa))
Walker, Andrea (City Hospital Zürich (Suïssa))
Lepeytre, Fanny (Claude Galien Hospital Ramsay Santé (França))
Rabaté, Clémentine (Claude Galien Hospital Ramsay Santé (França))
Rostoker, Guy (Claude Galien Hospital Ramsay Santé (França))
Marques, Sofia (Clínica de Hemodiálise de Felgueiras (Portugal))
Azasevac, Tijana (University of Novi Sad (Sèrbia))
Majstorovic, G.S. (University of Novi Sad (Sèrbia))
Katicic, D. (Croatian Society of Nephrology)
ten Dam, M. (CWZ Nijmegen)
Krüger, T. (DaVita Geilenkirchen)
Brzosko, S. (DaVita)
Liakopoulos, V. (Aristotle University of Thessaloniki)
Zanen, A.L. (Deventer Ziekenhuis)
Logtenberg, Susan J. J. (Dianet Dialysis Center (Països Baixos))
Fricke, Lutz (Dialysis Center Bochum (Alemanya))
Kuryata, Olexandr (Dnipro State Medical University)
Slebe, Jeroen J. P. (Elyse Klinieken Voor Nierzorg (Països Baixos))
Abd ElHafeez, Samar (High Institute of Public Health-Alexandria University (Egipte))
Kemlin, Delphine (Erasme Hospital (Bèlgica))
van de Wetering, Jacqueline (University Medical Center Rotterdam (Països Baixos))
Reinders, Marlies E. J. (University Medical Center Rotterdam (Països Baixos))
Hesselink, Dennis A. (University Medical Center Rotterdam (Països Baixos))
Kal-van Gestel, Judith A. (University Medical Center Rotterdam (Països Baixos))
Eiselt, Jaromír (Faculty of Medicine in Pilsen. Charles University (República Txeca))
Kielberger, Lukáš (Faculty of Medicine in Pilsen. Charles University (República Txeca))
El-Wakil, Hala S. (Faculty of Medicine-Alexandria University (Egipte))
Verhoeven, Martine A. M. (Franciscus Gasthuis & Vlietland (Països Baixos))
Logan, Ian R. (Freeman Hospital (Newcastle, Regne Unit))
Canal Girol, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Facundo, Carme (Institut d'Investigació Biomèdica Sant Pau)
Ramos, Ana Mazón (Hospital Universitario Fundación Jiménez Díaz)
Debska-Slizien, Maria Alicja (Gdansk Medical University (Polònia))
Veldhuizen, Nicoline M. H. (Gelre Hospital (Països Baixos))
Tigka, Eirini (General Hospital of Athens "G. Gennimatas" (Grècia))
Konsta, Maria Anna Polyzou (General Hospital of Serres (Grècia))
Panagoutsos, Stylianos A. (General University Hospital of Alexandroupolis (Grècia))
Mallamaci, Francesca (Grande Ospedale Metropolitano and CNR (Itàlia))
Postorino, Adele (Grande Ospedale Metropolitano and CNR (Itàlia))
Cambareri, Francesco (Grande Ospedale Metropolitano and CNR (Itàlia))
Matceac, Irina (Dr Ci Parhon Hospital (Romania))
Nistor, Ionuţ (Dr Ci Parhon Hospital (Romania))
Groeneveld, Jan H. Marc (Haaglanden Medisch Centrum (Països Baixos))
Jousma, Jolanda (Haaglanden Medisch Centrum (Països Baixos))
van Buren, Marjolijn (Haga Hospital (Països Baixos))
Diekmann, Fritz (Hospital Clínic i Provincial de Barcelona)
Oppenheimer, Federico (Hospital Clínic i Provincial de Barcelona)
Blasco Pelicano, Miquel (Hospital Clínic i Provincial de Barcelona)
Pereira, Tiago Assis (Hospital Curry Cabral-Central Lisbon University Hospital Center (Portugal))
Soares dos Santos, Augusto Cesar (Universidade Federal de Minas Gerais)
Arias Cabrales, Carlos E. (Hospital del Mar (Barcelona, Catalunya))
Crespo, Marta (Hospital del Mar (Barcelona, Catalunya))
Llinàs Mallol, Laura (Hospital del Mar (Barcelona, Catalunya))
Buxeda, Anna (Hospital del Mar (Barcelona, Catalunya))
Burballa, Carla (Hospital del Mar (Barcelona, Catalunya))
Redondo-Pachón, Dolores (Hospital del Mar (Barcelona, Catalunya))
Jimenez, Maria Dolores Arenas (Hospital del Mar (Barcelona, Catalunya))
Mendoza-Valderrey, Alberto (Hospital del Mar (Barcelona, Catalunya))
Martins, Ana Cristina (Centro Hospitalar de Lisboa Ocidental (Portugal))
Mateus, Catarina (Centro Hospitalar de Lisboa Ocidental (Portugal))
Alvila, Goncalo (Centro Hospitalar de Lisboa Ocidental (Portugal))
Laranjinha, Ivo J. (Centro Hospitalar de Lisboa Ocidental (Portugal))
Hofstra, Julia M. (Hospital Gelderse Vallei (Països Baixos))
Siezenga, Machiel A. (Hospital Gelderse Vallei (Països Baixos))
Franco Esteve, Antonio José Marin (Hospital General Universitario de Alicante (Alacant, País Valencià))
Arroyo, David (Hospital General Universitario Gregorio Marañón)
Castellano, Sandra (Hospital General Universitario Gregorio Marañón)
Rodríguez-Ferrero, Mariá Luisa (Hospital General Universitario Gregorio Marañón)
Manzanos, Sagrario Balda (Hospital Obispo Polanco (Terol, Aragó))
Barrios, R. Haridian Sosa (Hospital Universitario Ramón y Cajal (Madrid))
Lemahieu, Wim P. D. (Imelda Hospital (Bèlgica))
Bartelet, Karlijn (Isala (Països Baixos))
Dirim, Ahmet Burak (Istanbul University (Turquia))
Demir, Erol (Istanbul University (Turquia))
Sever, Mehmet Šükrü (Istanbul University (Turquia))
Turkmen, Aydin (Istanbul University (Turquia))
Şafak, Seda (Istanbul University (Turquia))
Hollander, Daan A. M. J. (Jeroen Bosch Ziekenhuis (Països Baixos))
Büttner, Stefan (Klinikum Aschaffenburg-Alzenau (Alemanya))
de Vries, Aiko P. J. (Leiden University Medical Center)
Meziyerh, Soufian (Leiden University Medical Center)
van der Helm, Danny (Leiden University Medical Center)
Mallat, Marko J. K. (Leiden University Medical Center)
Bouwsma, Hanneke (Leiden University Medical Center)
Sridharan, Sivakumar (Lister Hospital (Regne Unit))
Petruliene, Kristina (Lithuanian University of Health Sciences (Lituània))
Maloney, Sharon Rose (Luzerner Kantonsspital (Suïssa))
Verberk, Iris J. A. M. (Maasstad Ziekenhuis (Països Baixos))
van der Sande, Frank (Maastricht University Medical Center)
Christiaans, Maarten (Maastricht University Medical Center)
Hemmelder, Marc H. (Maastricht University Medical Center)
MohanKumar, N. (Manipal Hospital (Índia))
Di Luca, Marina (Marche Nord Hospital (Itàlia))
Tuğlular, Serhan Zubeyde (Marmara University School of Medicine (Turquia))
Kramer, Andrea B. (Martini Ziekenhuis (Països Baixos))
Beerenhout, Charles H. (Maxima Medisch Centrum (Països Baixos))
Luik, Peter T. (Meander Medisch Centrum (Països Baixos))
Kerschbaum, Julia (Medical University Innsbruck (Àustria))
Tiefenthaler, Martin (Medical University Innsbruck (Àustria))
Watschinger, Bruno H. (Medical University of Vienna)
Stepanov, Vadim A. (Moscow Regional Research and Clinical Institute (Rússia))
Zulkarnaev, Alexey (Moscow Regional Research and Clinical Institute (Rússia))
Turkmen, Kültigin (Necmettin Erbakan University Meram School of Medicine (Turquia))
Gandolfini, Ilaria (University of Parma (Itàlia))
Maggiore, Umberto (University of Parma (Itàlia))
Fliedner, Anselm (Nierenzentrum Reutlingen-Tübingen (Alemanya))
Åsberg, Anders (Oslo University Hospital-Rikshospitalet (Noruega))
Mjoen, Geir (Oslo University Hospital-Rikshospitalet (Noruega))
Miyasato, Hitoshi (Okinawa Chubu Hospital (Japó))
de Fijter, Caroline W.H. (OLVG (Països Baixos))
Mongera, Nicola (Ospedale S. Maurizio Bolzano)
Pini, Stefano (University Hospital of Padova (Pàdua, Itàlia))
de Biase, Consuelo (Radboud University Medical Center (Països Baixos))
Kerckhoffs, Angèle P. M. (Radboud University Medical Center (Països Baixos))
van de Logt, Anne Els (Radboud University Medical Center (Països Baixos))
Maas, Rutger J. H. (Radboud University Medical Center (Països Baixos))
Hilbrands, Luuk B. (Radboud University Medical Center (Països Baixos))
Lebedeva, Olga (Regional Clinical Hospital enis)
Lopez, Verónica (Hospital Regional Universitario de Málaga)
Reichert, Louis J. M. (Rijnstate Hospital (Països Baixos))
Verhave, Jacobien C. (Rijnstate Hospital (Països Baixos))
Titov, Denis (RUDN University (Rússia))
Parshina, Ekaterina (Saint-Petersburg State University Hospital (Rússia))
Zanoli, Luca (University of Catania (Itàlia))
Marcantoni, Carmelita (University of Catania (Itàlia))
van Kempen, Gijs (Saxenburgh Medisch Centrum (Països Baixos))
van Gils-Verrij, Liesbeth E .A. (Sint Antonius Ziekenhuis (Països Baixos))
Harty, John C. (Southern Health and Social Care Trust (Regne Unit))
Meurs, Marleen (Spaarne Gasthuis (Països Baixos))
Myslak, Marek (SPWSZ Hospital (Polònia))
Battaglia, Yuri (St. Anna University Hospital (Itàlia))
Lentini, Paolo (St. Bassiano Hospital (Itàlia))
den Deurwaarder, Edwin S. G. (Streekziekenhuis Koningin Beatrix (Països Baixos))
Stendahl, Maria E. (Swedish Renal Registry (Suècia))
Rahimzadeh, Hormat (Tehran University of Medical Sciences (Iran))
Rychlík, Ivan (Charles University (República Txeca))
Cabezas-Reina, Carlos Jesús (Toledo University Hospital)
Roca, Ana Maria (Toledo University Hospital (Estats Units d'Amèrica))
Nauta, Ferdau L. (Treant/Scheper Ziekenhuis (Països Baixos))
Sahin, Ídris (Turgut Ozal Medical Center (Turquia))
Goffin, Eric (Université Catholique de Louvain (Bèlgica))
Kanaan, Nada (Université Catholique de Louvain (Bèlgica))
Labriola, Laura (Université Catholique de Louvain (Bèlgica))
Devresse, Arnaud (Université Catholique de Louvain (Bèlgica))
Diaz-Mareque, Anabel Isabel (University Clinical Hospital of Santiago de Compostela)
Coca, Armando (Hospital Clínico Universitario de Valladolid)
de Arriba, Gabriel (Universitary Hospital of Guadalajara)
Meijers, Björn K. I. (UZ Leuven)
Naesens, Maarten (UZ Leuven)
Kuypers, Dirk R. J. (UZ Leuven)
Desschans, Bruno (UZ Leuven)
Tonnerlier, Annelies (University Hospital Brussels (Bèlgica))
Wissing, Karl Martin (University Hospital Brussels (Bèlgica))
Dedinska, Ivana (University Hospital Martin and Jessenius Faculty of Medicine Comenius University)
Pessolano, Giuseppina (University Hospital Medical Center Verona (Itàlia))
Malik, Shafi (University Hospitals Coventry and Warwickshire NHS Trust)
Dounousi, Evangelia C. (University Hospital of Ioannina (Grècia))
Papachristou, Evangelos (University Hospital of Patras (Grècia))
Berger, Stefan (University Medical Center Groningen (Països Baixos))
Sanders, Jan Stephan (University Medical Center Groningen (Països Baixos))
Franssen, Casper F. M. (University Medical Center Groningen (Països Baixos))
Özyilmaz, Akin (University Medical Center Groningen (Països Baixos))
Ponikvar, Jadranka (University Medical Center Ljubljana (Eslovènia))
Marn-Pernat, Andreja (University Medical Center Ljubljana (Eslovènia))
Kovac, D. (University Medical Center Ljubljana (Eslovènia))
Arnol, M. (University Medical Center Ljubljana (Eslovènia))
Ekart, R. (University Medical Centre Maribor)
Abrahams, A.C. (University Medical Center Utrecht)
Molenaar, F.M. (University Medical Center Utrecht)
van Zuilen, A.D. (University Medical Center Utrecht)
Meijvis, S.C.A. (University Medical Center Utrecht)
Dolmans, H. (University Medical Center Utrecht)
Tantisattamo, E. (University of California Irvine School of Medicine)
Esposito, P. (University of Genoa)
Krzesinski, J.M. (Université de Liège)
Barahira, J.D. (Université de Liège)
Gallieni, Maurizio (University of Milan)
Martin-Moreno, P.L. (Clínica Universidad de Navarra)
Guglielmetti, G. (University of Piemonte Orientale)
Guzzo, Gabriela (Valais Hospital. Sion & Lausanne University Hospital (Suïssa))
Toapanta, Néstor (Hospital Universitari Vall d'Hebron)
Soler, Maria Jose (Hospital Universitari Vall d'Hebron)
Luik, A.J. (VieCuri Medical Centre)
van Kuijk, W.H.M. (VieCuri Medical Centre)
Stikkelbroeck, L.W.H. (VieCuri Medical Centre)
Hermans, M.M.H. (VieCuri Medical Centre)
Rimsevicius, Laurynas (Vilnius University (Lituània))
Righetti, Marco (Vimercate Hospital (Itàlia))
Islam, Mahmud (Zonguldak Ataturk State Hospital)
Universitat Autònoma de Barcelona

Fecha:	2022
Resumen:	In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62. 0%, mean age 56. 4 years) and 3206 dialysis patients (male 61. 8%, mean age 67. 7 years) were examined. Three-month mortality in kidney transplant recipients was 16. 9% in males and 18. 6% in females (p = 0. 31) and in dialysis patients 27. 1% in males and 21. 9% in females (p = 0. 001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0. 89 (95% CI 65, 1. 23, p = 0. 49) in kidney transplant recipients and 1. 33 (95% CI 1. 13, 1. 56, p = 0. 001) in dialysis patients (p = 0. 02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1. 39 (95% CI 1. 02, 1. 89, p = 0. 04) in males and 2. 04 (95% CI 1. 40, 2. 97, p < 0. 001) in females (p = 0. 02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 17978, ISSN 2045-2322

DOI: 10.1038/s41598-022-22657-4
PMID: 36289317

13 p, 1.3 MB

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