Adipocytes in synovial fluid cytology : An approach for diagnosing synovial lipomatosis
Agulla, Beatriz (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Vizcaíno, Núria (Universitat Autònoma de Barcelona. Hospital Clínic Veterinari)
Velarde, Roser (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Estruch Morente, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Domínguez, Elisabet (Anicura Ars Veterinària Hospital Veterinari)
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2024
Abstract:	A 2-year-old neutered male bullmastiff dog was presented with chronic left hind limb lameness. Physical examination revealed left stifle effusion and medial buttress without cranial tibial thrust. Radiographs showed joint effusion and new bone formation at the patella apex. Magnetic resonance imaging showed increased synovial fluid, widening of the joint space, abnormal infrapatellar fat body and thinning of the cranial cruciate ligament. Synoviocentesis and cytologic evaluation of synovial fluid revealed marked mononuclear inflammation with abundant fatty tissue, suggesting synovial lipomatosis in conjunction with the imaging findings. The disease was confirmed histologically after sampling the lesion during arthrotomy. Synovial lipomatosis, characterized by extensive synovial adipose tissue proliferation of the synovial membrane, is a rare "tumor-like" disorder that usually affects the stifle. Although the etiology remains unclear, joint trauma, inflammation, instability, and lipid abnormalities have been proposed as causes. Inflammatory factors may promote synoviocyte and adipocyte hyperplasia that perpetuate the process. Surgical removal may be suggested to eliminate triggers and prevent future recurrences. The report provides the first cytological description of adipocytes in synovial fluid associated with the diagnosis of synovial lipomatosis in dogs. This case report underscores the potential effectiveness of cytologic analysis of synovial fluid smears, in combination with magnetic resonance imaging (MRI), for diagnosing this condition and reducing complications associated with arthrotomy for sampling purposes. Additionally, the case highlights that synovial lipomatosis should be considered as a potential differential diagnosis for synovial masses in dogs. Further cases are needed to validate these observations in veterinary medicine.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adipocytes ; Animals ; Dog Diseases ; Dogs ; Inflammation ; Joint Diseases ; Lipomatosis ; Male ; Stifle ; Synovial Fluid
Published in:	Veterinary Clinical Pathology, Vol. 53 Núm. 1 (march 2024) , p. 80-84, ISSN 1939-165X

DOI: 10.1111/vcp.13330
PMID: 38320970

5 p, 2.4 MB

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