The scene of lung pathology during PRRSV-1 infection
Ruedas-Torres, Inés (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)
Sánchez-Carvajal, José María (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)
Salguero, Francisco Javier (United Kingdom Health Security Agency)
Pallarés Martínez, Francisco José (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)
Carrasco, Librado (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)
Mateu de Antonio, Enrique María (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Gómez-Laguna, Jaime (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)
Rodríguez-Gómez, Irene Magdalena (Universidad de Córdoba Departamento de Anatomía y Patología y Toxicología Comparativas)

Date:	2024
Abstract:	Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases for the pig industry worldwide. The disease was firstly reported in 1987 and became endemic in many countries. Since then, outbreaks caused by strains of high virulence have been reported several times in Asia, America and Europe. Interstitial pneumonia, microscopically characterised by thickened alveolar septa, is the hallmark lesion of PRRS. However, suppurative bronchopneumonia and proliferative and necrotising pneumonia are also observed, particularly when a virulent strain is involved. This raises the question of whether the infection by certain strains results in an overstimulation of the proinflammatory response and whether there is some degree of correlation between the strain involved and a particular pattern of lung injury. Thus, it is of interest to know how the inflammatory response is modulated in these cases due to the interplay between virus and host factors. This review provides an overview of the macroscopic, microscopic, and molecular pathology of PRRSV-1 strains in the lung, emphasising the differences between strains of different virulence.
Grants:	Ministerio de Economía y Competitividad PID2019-109718GB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	PRRSV-1 ; Pathology ; Lung ; Interstitial pneumonia ; Bronchopneumonia ; Inflammation ; Virulence
Published in:	Frontiers in Veterinary Science, Vol. 11 (march 2024) , ISSN 2297-1769

DOI: 10.3389/fvets.2024.1330990
PMID: 38566751

14 p, 9.4 MB

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