Perspectives and challenges in patient stratification in Alzheimer's disease
Abdelnour, Carla (Universitat Autònoma de Barcelona)
Agosta, Federica (Vita-Salute San Raffaele University)
Bozzali, Marco (University of Turin)
Fougère, Bertrand (Tours University Hospital)
Iwata, Atsushi. (Tokyo Metropolitan Geriatric Hospital)
Nilforooshan, Ramin. (UK Dementia Research Institute - Care Research and Technology Centre)
Takada, Leonel T. (University of São Paulo)
Viñuela, Félix (University of Seville)
Traber, Martin (Hoffmann-La Roche Ltd.)

Date:	2022
Abstract:	Background: Patient stratification is the division of a patient population into distinct subgroups based on the presence or absence of particular disease characteristics. As patient stratification can be used to account for the underlying pathology of a disease, it can help physicians to tailor therapeutic interventions to individuals and optimize their care management and treatment regime. Alzheimer's disease, the most common form of dementia, is a heterogeneous disease and its management benefits from patient stratification in clinical trials, and the development of personalized care and treatment strategies for people living with the disease. Main body: In this review, we discuss the importance of the stratification of people living with Alzheimer's disease, the challenges associated with early diagnosis and patient stratification, and the evolution of patient stratification once disease-modifying therapies become widely available. Conclusion: Patient stratification plays an important role in drug development in clinical trials and may play an even larger role in clinical practice. A timely diagnosis and stratification of people living with Alzheimer's disease is paramount in determining people who are at risk of progressing from mild cognitive impairment to Alzheimer's dementia. There are key issues associated with stratifying patients which include the heterogeneity and complex neurobiology behind Alzheimer's disease, our inadequately prepared healthcare systems, and the cultural perceptions of Alzheimer's disease. Stratifying people living with Alzheimer's disease may be the key in establishing precision and personalized medicine in the field, optimizing disease prevention and pharmaceutical treatment to slow or stop cognitive decline, while minimizing adverse effects.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Subject:	Alzheimer's disease ; Biomarkers ; Cultural perceptions of dementia ; Dementia ; Disease-modifying therapy ; Early diagnosis ; Mild cognitive impairment ; Patient stratification ; Precision medicine ; Stigma
Published in:	Alzheimer's research & therapy, Vol. 14 Núm. 1 (december 2022) , p. 112, ISSN 1758-9193

DOI: 10.1186/s13195-022-01055-y
PMID: 35964143

12 p, 1.1 MB

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