Different Types of Glucocorticoids to Evaluate Stress and Welfare in Animals and Humans : General Concepts and Examples of Combined Use
Botía, María (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Escribano Tortosa, Damián (Universidad de Murcia. Departamento de Producción Animal)
Martínez-Subiela, Silvia (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Tvarijonaviciute, Asta (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Tecles, Fernando (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
López-Arjona, Marina (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)
Cerón, José Joaquín (Universidad de Murcia. Laboratorio Interdisciplinario de Análisis Clínicos Interlab)

Date:	2023
Abstract:	The main glucocorticoids involved in the stress response are cortisol and cortisone in most mammals and corticosterone in birds and rodents. Therefore, these analytes are currently the biomarkers more frequently used to evaluate the physiological response to a stressful situation. In addition, "total glucocorticoids", which refers to the quantification of various glucocorticoids by immunoassays showing cross-reactivity with different types of glucocorticoids or related metabolites, can be measured. In this review, we describe the characteristics of the main glucocorticoids used to assess stress, as well as the main techniques and samples used for their quantification. In addition, we analyse the studies where at least two of the main glucocorticoids were measured in combination. Overall, this review points out the different behaviours of the main glucocorticoids, depending on the animal species and stressful stimuli, and shows the potential advantages that the measurement of at least two different glucocorticoid types can have for evaluating welfare.
Grants:	Agencia Estatal de Investigación PDC2021-121291-I00 European Commission 862919
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Glucocorticoids ; Cortisol ; Cortisone ; Corticosterone ; Measurement ; Stress
Published in:	Metabolites, Vol. 13, Issue 1 (January 2023) , art. 106, ISSN 2218-1989

DOI: 10.3390/metabo13010106
PMID: 36677031

13 p, 1.5 MB

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