Recruitment of frontal sensory circuits during visual discrimination
Broom, Eluned (Cardiff University)
Imbriotis, Vivian (University of Tasmania)
Sengpiel, Frank (Cardiff University)
Connelly, William M. (University of Tasmania)
Ranson, Adam (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2022
Abstract:	A long-range circuit linking the medial frontal cortex to the primary visual cortex (V1) has been proposed to mediate visual selective attention in mice during visually guided behavior. Here, we use in vivo two-photon functional imaging to measure the endogenous activity of axons of A24b/M2 neurons from this region projecting to layer 1 of V1 (A24b/M2-V1) in mice either passively viewing stimuli or performing a go/no-go visually guided task. We observe that while A24b/M2-V1 are recruited under these conditions, this is not linked to enhancement of neural or behavioral measures of sensory coding. Instead, A24b/M2-V1 activity is associated with licking behavior, modulated by reward, and biased toward the sensory cortical hemisphere representing the stimulus currently being discriminated. Broom et al. test the link between increased endogenous A24b/M2-V1 axon activity and enhanced visual processing and visually guided behavior. They find no evidence of this association and instead observe that A24b/M2-V1 axon activity is correlated with licking and modulated by reward.
Grants:	Agencia Estatal de Investigación 2019-109285GA-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anterior cingulate cortex ; Attention ; CP: Neuroscience ; Feedback ; Primary visual còrtex ; Top-down ; Vision
Published in:	Cell reports, Vol. 39 (june 2022) , ISSN 2211-1247

DOI: 10.1016/j.celrep.2022.110932
PMID: 35675774

15 p, 2.5 MB

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