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| Home > Articles > Published articles > The early-life exposome modulates the effect of polymorphic inversions on DNA methylation |
(Institut de Salut Global de Barcelona) (Universitat Politècnica de Catalunya) (Institut de Salut Global de Barcelona) (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) (Vytautas Magnus University. Department of Environmental Science) (Fundación Pública Galega de Medicina Xenómica) (Vytautas Magnus University. Department of Environmental Science) (Université Grenoble-Alpes) (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) (Bradford Institute for Health Research) (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) (Hospital del Mar (Barcelona, Catalunya)) (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
| Date: | 2022 |
| Abstract: | Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23. 1, 16p11. 2, and 17q21. 31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23. 1 and higher meat intake were more susceptible to TDH hypermethylation (P = 3. 8 × 10 -22); being the inversion, exposure, and gene known risk factors for adult obesity. Inv-8p23. 1 associated hypermethylation of GATA4 was also detected across numerous exposures. Our data suggests that the pleiotropic influence of inversions during development and lifetime could be substantially mediated by allele-specific methylation patterns which can be modulated by the exposome. Analysis of the relationship between presence of common DNA sequence inversions and DNA methylation patterns suggests a role for environmental exposures (such as food intake) in mediating inversion state-specific methylation patterns. |
| Grants: | European Commission 308333 European Commission 874583 Instituto de Salud Carlos III PI17/01225 Instituto de Salud Carlos III PI17/01935 European Commission 211250 European Commission 226285 Agencia Estatal de Investigación RTI2018-100789-B-I00 Ministerio de Ciencia e Innovación CEX2018-000806-S Ministerio de Economía y Competitividad MDM-2014-0370 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-01974 Fundació la Marató de TV3 2015-3230 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | DNA methylation ; Genetic interaction ; Risk factors |
| Published in: | Communications Biology, Vol. 5 (May 2022) , art. 455, ISSN 2399-3642 |
