The Second Wind in McArdle Patients : Fitness Matters
Salazar-Martínez, Eduardo (Centro de Estudios. Universitarios Cardenal Spínola-CEU)
Santalla, Alfredo (Universidad Europea de Canarias. EVOPRED Research Group)
Valenzuela, Pedro L. (Universidad Europea de Madrid)
Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pinós Figueras, Tomàs (Vall d'Hebron Institut de Recerca (VHIR))
Morán, María (Instituto de Investigación Sanitaria 12 de Octubre)
Santos-Lozano, Alejandro (Instituto de Investigación Sanitaria 12 de Octubre)
Fiuza-Luces, Carmen (Instituto de Investigación Sanitaria 12 de Octubre)
Lucia, Alejandro (Instituto de Investigación Sanitaria 12 de Octubre)

Data:	2021
Resum:	Background: The "second wind" (SW) phenomenon-commonly referring to both an initial period of marked intolerance to dynamic exercise (e. g. , brisk walking) that is not followed by perceived improvement and disappearance of previous tachycardia (i. e. , the actual "SW") until 6-10 min has elapsed-is an almost unique feature of McArdle disease that limits adherence to an active lifestyle. In this regard, an increase in the workload eliciting the SW could potentially translate into an improved patients' exercise tolerance in daily life. We aimed to determine whether aerobic fitness and physical activity (PA) levels are correlated with the minimum workload eliciting the SW in McArdle patients-as well as with the corresponding heart rate value. We also compared the SW variables and aerobic fitness indicators in inactive vs. active patients. Methods: Fifty-four McArdle patients (24 women, mean ± SD age 33 ± 12 years) performed 12-min constant-load and maximum ramp-like cycle-ergometer tests for SW detection and aerobic fitness [peak oxygen uptake (VO ) and workload and ventilatory threshold] determination, respectively. They were categorized as physically active/inactive during the prior 6 months (active = reporting ≥150 min/week or ≥75 min/week in moderate or vigorous-intensity aerobic PA, respectively) and were also asked on their self-report of the SW. Results: Both peak and submaximal indicators of aerobic fitness obtained in the ramp tests were significantly correlated with the workload of the SW test, with a particularly strong correlation for the VO and peak workload attained by the patients (both Pearson's coefficients.
Ajuts:	Instituto de Salud Carlos III PI18/00139 Instituto de Salud Carlos III PI20/00645 Instituto de Salud Carlos III PI17/00093 Instituto de Salud Carlos III PI18/00713 Instituto de Salud Carlos III PI19/01313
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Frontiers in physiology, Vol. 12 (15 2021) , p. 744632, ISSN 1664-042X

DOI: 10.3389/fphys.2021.744632
PMID: 34721068

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