Interaction of Energy Drinks with Prescription Medication and Drugs of Abuse
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Martín, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Barriocanal, Ana María (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Farré Albaladejo, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Date:	2021
Abstract:	In recent years, the consumption of energy drinks (EDs) has become increasingly popular, especially among adolescents. Caffeine, a psychostimulant, is the main compound of EDs which also contain other substances with pharmacological effects. This review aims to compile current evidence concerning the potential interactions between EDs, medicines, and drugs of abuse as they are frequently consumed in combination. The substances involved are mainly substrates, inductors or inhibitors of CYP1A2, psychostimulants, alcohol and other depressant drugs. Furthermore, intoxications reported with EDs and other substances have also been screened to describe acute toxicity. The results of our review show that the consumption of both EDs alone and in combination is not as safe as previously thought. Health professionals and consumers need to be aware of the potential interactions of these drinks as well as the absence of long-term safety data.
Grants:	Ministerio de Sanidad, Servicios Sociales e Igualdad 2018I037 Ministerio de Sanidad, Servicios Sociales e Igualdad 2016I024 Instituto de Salud Carlos III RD16/0017/0003 Generalitat de Catalunya 2017SGR316 Instituto de Salud Carlos III FI18/00179
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Energy drinks ; Caffeine ; Drug interactions ; Pharmacokinetics
Published in:	Pharmaceutics, Vol. 13 (september 2021) , ISSN 1999-4923

DOI: 10.3390/pharmaceutics13101532
PMID: 34683828

16 p, 360.5 KB

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