Utilisation Trend of Long-Acting Insulin Analogues including Biosimilars across Europe : Findings and Implications
Godman, Brian (Universiti Sains Malaysia (Penang, Malàsia))
Wladysiuk, Magdalena (HTA Consulting (Krakow, Polònia))
McTaggart, Stuart (Public Health Scotland (Edinburg, Regne Unit))
Kurdi, Amanj (Hawler Medical University (Erbil, Iraq))
Allocati, Eleonora (Istituto di Ricerche Farmacologiche 'Mario Negri' (Milan, Itàlia))
Jakovljevic, Mihajlo (Hosei University Tokyo)
Kalemeera, Francis (Department of Pharmacy Practice and Policy, Faculty of Health Sciences, University of Namibia)
Hoxha, Iris (Department of Pharmacy, Faculty of Medicine, University of Medicine (Tirana, Albània))
Nachtnebel, Anna (Dachverband der Österreichischen Sozialversicherungen (Viena, Austria))
Sauermann, Robert (Dachverband der Österreichischen Sozialversicherungen (Viena, Austria))
Hinteregger, Manfred (Dachverband der Österreichischen Sozialversicherungen (Viena, Austria))
Marković-Peković, Vanda (Faculty of Medicine, Department of Social Pharmacy, University of Banja Luka (Banja Luka, Bòsnia i Hercegovina))
Tubic, Biljana (Agency for Medicinal Product and Medical Devices of Bosnia and Herzegovina (Banja Luka, Bòsnia i Hercegovina))
Petrova, Guenka (Medical University of Sofia (Sofia, Bulgària))
Tachkov, Konstantin (Medical University of Sofia (Sofia, Bulgària))
Slabý, Juraj (State Institute for Drug Control (Praga, República Txeca))
Nejezchlebova, Radka (State Institute for Drug Controlic (Praga, República Txeca))
Krulichová, Iva Selke (Charles University (Hradec Králové, República Txeca). Department of Medical Biophysics)
Laius, Ott (State Agency of Medicines (Tartu, Estònia))
Selke, Gisbert (Wissenschaftliches Institut der AOK (Berlin, Alemanya))
Langner, Irene (Wissenschaftliches Institut der AOK (Berlin, Alemanya))
Harsanyi, András (Eotvos Lorand University (Budapest, Hongria). Department of Health Policy and Health Economics)
Inotai, András (Semmelweis University (Budapest, Hongria). Center of Health Technology Assessment)
Jakupi, Arianit (UBT Higher Education Institute (Pristina, Kosovo))
Henkuzens, Svens
Garuolienė, Kristina (Vilnius University (Vilnius, Lituània))
Gulbinovič, Jolanta (Vilnius University (Vilnius, Lituània))
Bonanno, Patricia Vella (University of Malta (Valletta, Malta). Department of Health Services Management)
Rutkowski, Jakub (HTA Consulting (Krakow, Polònia))
Ingeberg, Skule (Oslo University Hospital (Oslo, Noruega))
Melien, Øyvind (Oslo University Hospital (Oslo, Noruega))
Mardare, Ileana ("Carol Davila" University of Medicine and Pharmacy Bucharest (Bucarest, Rumania))
Fürst, Jurij (Health Insurance Institute (Ljubljana, Eslovènia))
MacBride-Stewart, Sean (Pharmacy Services, Greater Glasgow and Clyde)
Holmes, Carol (NHS Lothian, Edinburgh, UK)
Pontes García, Caridad (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Zara, Corinne (Servei Català de la Salut)
Pedrola, Marta Turu (Servei Català de la Salut)
Hoffmann, Mikael (NEPI-Nätverk för läkemedelsepidemiologi (Stockholm, Suècia))
Kourafalos, Vasileios (National Organization for the Provision of Healthcare Services (Atenes, Grècia))
Pisana, Alice (Karolinska Institutet (Stockholm, Suècia))
Banzi, Rita (IRCCS Istituto Giannina Gaslini (Gènova, Itàlia))
Campbell, Stephen (University of Manchester)
Wettermark, Bjorn (Uppsala University (Uppsala, Suècia))

Data:	2021
Resum:	Diabetes mellitus rates and associated costs continue to rise across Europe enhancing health authority focus on its management. The risk of complications is enhanced by poor glycaemic control, with long-acting insulin analogues developed to reduce hypoglycaemia and improve patient convenience. There are concerns though with their considerably higher costs, but moderated by reductions in complications and associated costs. Biosimilars can help further reduce costs. However, to date, price reductions for biosimilar insulin glargine appear limited. In addition, the originator company has switched promotional efforts to more concentrated patented formulations to reduce the impact of biosimilars. There are also concerns with different devices between the manufacturers. As a result, there is a need to assess current utilisation rates for insulins, especially long-acting insulin analogues and biosimilars, and the rationale for patterns seen, among multiple European countries to provide future direction. Methodology. Health authority databases are examined to assess utilisation and expenditure patterns for insulins, including biosimilar insulin glargine. Explanations for patterns seen were provided by senior-level personnel. Typically increasing use of long-acting insulin analogues across Europe including both Western and Central and Eastern European countries reflects perceived patient benefits despite higher prices. However, activities by the originator company to switch patients to more concentrated insulin glargine coupled with lowering prices towards biosimilars have limited biosimilar uptake, with biosimilars not currently launched in a minority of European countries. A number of activities were identified to address this. Enhancing the attractiveness of the biosimilar insulin market is essential to encourage other biosimilar manufacturers to enter the market as more long-acting insulin analogues lose their patents to benefit all key stakeholder groups. There are concerns with the availability and use of insulin glargine biosimilars among European countries despite lower costs. This can be addressed.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	BioMed Research International, Vol. 2021 (october 2021) , ISSN 2314-6141

DOI: 10.1155/2021/9996193
PMID: 34676266

16 p, 711.8 KB

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