Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Mitjans, M. (Universitat de Barcelona)
Hartman, CA. (Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen)
Artigas, M. Soler (Universitat de Barcelona)
Demontis, Ditte (Broad Institute of MIT and Harvard (Cambridge, Estats Units d'Amèrica))
Larsson, Henrik (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Kuntsi, J. (King's College London)
Faraone, Stephen V. (SUNY Upstate Medical University)
Børglum, AD. (Center for Genomics and Personalized Medicine (Aarhus, Dinamarca))
Reif, Andreas (Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University (Frankfurt, Alemanya))
Franke, Barbara (Radboud University Medical Center (Nijmegen, Holanda))
Cormand, Bru (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.
Ayudas:	European Commission 667302 European Commission 728018 Ministerio de Ciencia, Innovación y Universidades PID2021-1277760B-I100 Fundació la Marató de TV3 202218-31 European Commission 848228 European Commission 841899 European Commission 101028810 Instituto de Salud Carlos III PI20/00041 Ministerio de Ciencia e Innovación CP09/00119 Ministerio de Economía y Competitividad CPII15/00023 Agencia Estatal de Investigación 10.13039/501100011033 Ministerio de Ciencia e Innovación PID2022-139740OA-100 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-1093 Generalitat de Catalunya SLT006/17/287 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-146 Fundació la Marató de TV3 202228-30 Fundació la Marató de TV3 202228-31 Instituto de Salud Carlos III P19/01224 Instituto de Salud Carlos III PI22/00464 Instituto de Salud Carlos III CP22/00128 European Commission 847879 European Commission 965381
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Attention-deficit/hyperactivity disorder ; Comorbitidy ; Pleiotropy ; Cross-disorder genetics ; Genome-wide association study ; Genetic correlation ; Polygenic risk score
Publicado en:	Neuroscience & biobehavioral reviews, Vol. 153 (july 2023) , p. 105313, ISSN 1873-7528

DOI: 10.1016/j.neubiorev.2023.105313
PMID: 37451654

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