Insulin secretion in patients with latent autoimmune diabetes (LADA) : Half way between type 1 and type 2 diabetes: Action LADA 9
Hernandez, Marta (Hospital Universitari Arnau de Vilanova)
Mollo, Àngels (Institut Català de la Salut)
Marsal, Josep Ramon (Hospital Universitari Vall d'Hebron)
Esquerda, Aureli (Hospital Universitari Arnau de Vilanova)
Capel Flores, Ismael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pozzilli, Paolo (Queen Mary University of London)
De Leiva Hidalgo, Alberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Mauricio Puente, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Fecha:	2015
Resumen:	Background: The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes. Methods: Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n=32), type 1 diabetes mellitus (n=33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years. Results: At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed. Conclusions: The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	C-peptide ; Insulin secretion ; Latent autoimmune diabetes in adults ; Type 1 diabetes mellitus ; Type 2 diabetes mellitus
Publicado en:	BMC Endocrine Disorders, Vol. 15 Núm. 1 (december 2015) , p. 1, ISSN 1472-6823

DOI: 10.1186/1472-6823-15-1
PMID: 25572256

6 p, 299.0 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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