Management of Pediatric Mild Traumatic Brain Injury Patients : S100b, Glial Fibrillary Acidic Protein, and Heart Fatty-Acid-Binding Protein Promising Biomarkers
Chiollaz, Anne-Cécile (University of Geneva)
Pouillard, Virginie (Geneva University Hospitals (Suïssa))
Spigariol, Fabian (Neuchâtel Hospital (Suïssa))
Romano, Fabrizio (Inselspital Bern University Hospital)
Seiler, Michelle (University Children's Hospital Zurich (Zúric, Suïssa))
Schenk, Céline Ritter (Fribourg Hospital)
Korff, Christina (Geneva University Hospitals (Suïssa))
Habre, Céline (Geneva University Hospitals)
Maréchal, Fabienne (Geneva University Hospitals (Suïssa))
Wyss, Verena (Inselspital Bern University Hospital)
Gruaz, Lyssia (University of Geneva)
Lamana-Vallverdu, Marcel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Chocano, Elvira (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sempere Bordes, Lluis (Instituto de Biomedicina de Sevilla)
Luaces-Cubells, Carlos (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Méndez Hernández, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Cadenas, José Antonio (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Méndez Linde, María (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
de la Torre Sanchez, Paula (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Montaner, José (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Manzano, Sergio (University of Geneva)
Sanchez, Jean-Charles (IUniversity of Geneva)

Fecha:	2024
Resumen:	Children are highly vulnerable to mild traumatic brain injury (mTBI). Blood biomarkers can help in their management. This study evaluated the performances of biomarkers, in discriminating between children with mTBI who had intracranial injuries (ICIs) on computed tomography (CT+) and (1) patients without ICI (CT-) or (2) both CT- and in-hospital-observation without CT patients. The aim was to rule out the need of unnecessary CT scans and decrease the length of stay in observation in the emergency department (ED). Newborns to teenagers (£16 years old) with mTBI (Glasgow Coma Scale > 13) were included. S100b, glial fibrillary acidic protein (GFAP), and heart fatty-acid-binding protein (HFABP) performances to identify patients without ICI were evaluated through receiver operating characteristic curves, where sensitivity was set at 100%. A total of 222 mTBI children sampled within 6 h since their trauma were reported. Nineteen percent (n = 43/222) underwent CT scan examination, whereas the others (n = 179/222) were kept in observation at the ED. Sixteen percent (n = 7/43) of the children who underwent a CT scan had ICI, corresponding to 3% of all mTBI-included patients. When sensibility (SE) was set at 100% to exclude all patients with ICI, GFAP yielded 39% specificity (SP), HFABP 37%, and S100b 34% to rule out the need of CT scans. These biomarkers were even more performant: 52% SP for GFAP, 41% for HFABP, and 39% for S100b, when discriminating CT+ versus both in-hospital-observation and CT- patients. These markers can significantly help in the management of patients in the ED, avoiding unnecessary CT scans, and reducing length of stay for children and their families.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Neurotrauma Reports, Vol. 5 Núm. 1 (31 2024) , p. 529-539, ISSN 2689-288X

DOI: 10.1089/neur.2024.0027
PMID: 39071980

11 p, 1.3 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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