Brain metabolism response to intrahospital transfers in neurocritical ill patients and the impact of microdialysis probe location
Pedrosa, Leire (Hospital Clínic i Provincial de Barcelona)
Hoyos, Jhon (Hospital Clínic i Provincial de Barcelona)
Reyes, Luís (Hospital Clínic i Provincial de Barcelona)
Mosteiro, Alejandra (Hospital Clínic i Provincial de Barcelona)
Zattera, Luigi (Hospital Clínic i Provincial de Barcelona)
Topczewski, Tthomaz (Hospital Clínic i Provincial de Barcelona)
Rodríguez-Hernández, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Amaro, Sergio (Hospital Clínic i Provincial de Barcelona)
Torné, Ramon (Hospital Clínic i Provincial de Barcelona)
Enseñat, Joaquim (Hospital Clínic i Provincial de Barcelona)

Fecha:	2024
Resumen:	Intrahospital transfer (IHT), a routine in the management of neurocritical patients requiring imaging or interventions, might affect brain metabolism. Studies about IHT effects using microdialysis (MD) have produced conflicting results. In these studies, only the most damaged hemisphere was monitored, and those may not reflect the impact of IHT on overall brain metabolism, nor do they address differences between the hemispheres. Herein we aimed to quantify the effect of IHT on brain metabolism by monitoring both hemispheres with bilateral MD. In this study, 27 patients with severe brain injury (10 traumatic brain injury and 17 subarachnoid hemorrhage patients) were included, with a total of 67 IHT. Glucose, glycerol, pyruvate and lactate were measured by MD in both hemispheres for 10 h pre- and post-IHT. Alterations in metabolite levels after IHT were observed on both hemispheres; although these changes were more marked in hemisphere A (most damaged) than B (less damaged). Our results suggest that brain metabolism is altered after an IHT of neurocritical ill patients particularly but not limited to the damaged hemisphere. Bilateral monitorization may be more sensitive than unilateral monitorization for detecting metabolic disturbances not directly related to the course of the disease.
Ayudas:	Instituto de Salud Carlos III PI19/00936
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Microdialysis monitoring ; Brain metabolism ; Intrahospital transfer ; Neurocritical patients ; Traumatic brain injury ; Subarachnoid hemorrhage
Publicado en:	Scientific reports, Vol. 14 Núm. 1 (december 2024) , p. 7388, ISSN 2045-2322

DOI: 10.1038/s41598-024-57217-5
PMID: 38548829

16 p, 1.3 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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