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| Home > Articles > Published articles > Graphene-based microelectrodes with bidirectional functionality for next-generation retinal electronic interfaces |
(Institut Català de Nanociència i Nanotecnologia) (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) (Institut Català de Nanociència i Nanotecnologia) (Instituto de Salud Carlos III) (Sorbonne Université (França)) (Institut Català de Nanociència i Nanotecnologia) (Institut de Física d'Altes Energies) (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) (Institut Català de Nanociència i Nanotecnologia) (Institut de Física d'Altes Energies) (Institut de Ciència i Tecnologia de Barcelona. Institut de Recerca en Biomedicina) (Sorbonne Université) (Institut Català de Nanociència i Nanotecnologia)
| Date: | 2024 |
| Abstract: | Neuroelectronic prostheses are being developed for restoring vision at the retinal level in patients who have lost their sight due to photoreceptor loss. The core component of these devices is the electrode array, which enables interfacing with retinal neurons. Generating the perception of meaningful images requires high-density microelectrode arrays (MEAs) capable of precisely activating targeted retinal neurons. Achieving this precision necessitates the downscaling of electrodes to micrometer dimensions. However, miniaturization increases electrode impedance, which poses challenges by limiting the amount of current that can be delivered, thereby impairing the electrode's capability for effective neural modulation. Additionally, it elevates noise levels, reducing the signal quality of the recorded neural activity. This report focuses on evaluating reduced graphene oxide (rGO) based devices for interfacing with the retina, showcasing their potential in vision restoration. Our findings reveal low impedance and high charge injection limit for microscale rGO electrodes, confirming their suitability for developing next-generation high-density retinal devices. We successfully demonstrated bidirectional interfacing with cell cultures and explanted retinal tissue, enabling the identification and modulation of multiple cells' activity. Additionally, calcium imaging allowed real-time monitoring of retinal cell dynamics, demonstrating a significant reduction in activated areas with small-sized electrodes. Overall, this study lays the groundwork for developing advanced rGO-based MEAs for high-acuity visual prostheses. |
| Grants: | "la Caixa" Foundation 100010434 European Commission 881603 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-001534 Agencia Estatal de Investigación RYC2019-027879-I Agencia Estatal de Investigación FJC2021-046601-I Agencia Estatal de Investigación PID2020-113663RB-I00 Agencia Estatal de Investigación SEV-2017-0706 Agencia Estatal de Investigación CEX2021-001214-S European Commission 861423 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Published in: | Nanoscale horizons, Vol. 9, Issue 11 (September 2024) , p. 1948-1961, ISSN 2055-6764 |
