Last twenty-years activity of cardiovascular tissue banking in Barcelona
Castells-Sala, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Pérez, María Luisa (Vall d'Hebron Institut de Recerca (VHIR))
Agustí, Elba (Vall d'Hebron Institut de Recerca (VHIR))
Aiti, A. (Universitat Autònoma de Barcelona. Banc de Sang i Teixits)
Tarragona, E. (Universitat Autònoma de Barcelona. Banc de Sang i Teixits)
Navarro, Aurora (Organització Catalana de Trasplantaments (OCATT))
Tabera, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Fariñas Barbera, Oscar (Institut d'Investigació Biomèdica Sant Pau)
Pomar, José Luis (Hospital Clínic i Provincial de Barcelona)
Vilarrodona, Anna (Vall d'Hebron Institut de Recerca (VHIR))
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	The Barcelona Tissue Bank was established from the merge of two previous multi-tissue banks. Potential donors are screened by Donor Center staff and multi-tissue retrieval is performed by specialized own teams. Tissue processing and preservation is performed in clean room facilities by specialised personnel. After quality control of both donor and all tissues results, the heart valves and vascular segments are stored until medical request. The aim of this report is to present the cardiovascular tissue activity and retrospectively evaluate the outcomes of the changes performed in last 20 years. Cardiovascular tissue from 4088 donors was received, specifically 3115 hearts and 2095 vascular segments were processed and evaluated. A total of 48% of the aortic valves, 68% of the pulmonary valves and 75% of the vascular segments were suitable for transplant. The main reason for discarding tissue was macroscopic morphology followed by microbiological results, for both valves and arteries. Altogether, 4360 tissues were distributed for transplantation: 2032 (47%) vascular segments, 1545 (35%) pulmonary valves and 781 (18%) aortic valves. The most common indication for aortic valve surgery was the treatment of endocarditis, while for pulmonary valves, it was congenital malformation reconstruction. Vascular segments were mainly used for reconstruction after ischemia. During this period, a number of changes were made with the goal of enhancing tissue quality, safety and efficacy. These improvements were achieved through the use of a new antibiotic cocktail, increasing of donor age criteria and changing the microbiological control strategy.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Banking ; Cardiovascular ; Heart valves ; Homograft ; Tissue establishment ; Vascular segments
Publicado en:	Cell and Tissue Banking, Vol. 25 Núm. 1 (march 2024) , p. 11-26, ISSN 1573-6814

DOI: 10.1007/s10561-022-10059-9
PMID: 36849631

16 p, 1.7 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
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