Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease
van Keulen, Anne-Marleen (Erasmus MC Cancer Institute (Rotterdam, Holanda))
Buettner, Stefan (Erasmus MC Cancer Institute (Rotterdam, Holanda))
Olthof, Pim B. (Erasmus MC Cancer Institute (Rotterdam, Holanda))
Klümpen, Heinz-Josef (Universiteit van Amsterdam)
Erdmann, Joris I. (Universiteit van Amsterdam)
Izquierdo-Sanchez, Laura (Instituto de Salud Carlos III)
Banales, Jesus (Instituto de Salud Carlos III)
Goeppert, Benjamin (Heidelberg University Hospital (Alemanya))
Roessler, Stephanie (Heidelberg University Hospital (Alemanya))
Zieniewicz, Krzysztof (Medical University of Warsaw)
Lamarca, Angela (University of Manchester)
Valle, Juan W. (University of Manchester)
La Casta, Adelaida (OSI Donostialdea)
Hoogwater, Frederik J. H. (University of Groningen)
Donadon, Matteo (IRCCS Humanitas Research Hospital (Milan, Itàlia))
Scheiter, Alexander (University of Regensburg)
Marzioni, Marco (Universita Politecnica delle Marche (Ancona, Itàlia))
Adeva, Jorge (Hospital 12 de Octubre (Madrid))
Kiudeliene, Edita (Lithuanian University of Health Sciences)
Fernández, Jesús María Urman (Complejo Hospitalario de Navarra)
Vidili, Gianpaolo (Azienda Ospedaliero Universitaria (Sassari, Itàlia))
Mocan, Tudor (Babeș-Bolyai University (Cluj-Napoca, Rumania))
Fabris, Luca (Yale University School of Medicine)
Krawczyk, Marcin (Saarland University Medical Center)
Folseraas, Trine (Oslo University Hospital (Oslo, Noruega))
Dopazo, Cristina (Vall d'Hebron Institut de Recerca (VHIR))
Detry, Olivier (Université de Liège)
Voiosu, Theodor (Colentina Clinical Hospital (Bucharest, Rumania))
Scripcariu, Viorel (University of Medicine and Pharmacy "Gr T Popa" (Iasi, Rumania))
Biancaniello, Francesca (Università degli Studi di Roma "La Sapienza")
Braconi, Chiara (University of Glasgow)
Macias, Rocio I. R. (University of Salamanca)
Groot Koerkamp, Bas (Erasmus MC Cancer Institute (Rotterdam, Holanda))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Resection of perihilar cholangiocarcinoma (pCCA) is a complex procedure with a high risk of postoperative mortality and early disease recurrence. The objective of this study was to compare patient characteristics and overall survival (OS) between pCCA patients who underwent an R1 resection and patients with localized pCCA who received palliative systemic chemotherapy. Patients with a diagnosis of pCCA between 1997-2021 were identified from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) registry. pCCA patients who underwent an R1 resection were compared with patients with localized pCCA (i. e. , nonmetastatic) who were ineligible for surgical resection and received palliative systemic chemotherapy. The primary outcome was OS. Overall, 146 patients in the R1 resection group and 92 patients in the palliative chemotherapy group were included. The palliative chemotherapy group more often underwent biliary drainage (95% vs. 66%, p < 0. 001) and had more vascular encasement on imaging (70% vs. 49%, p = 0. 012) and CA 19. 9 was more frequently.
Grants:	European Commission 825510
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Annals of Surgical Oncology, Vol. 31 (june 2024) , p. 6495-6503, ISSN 1534-4681

DOI: 10.1245/s10434-024-15582-5
PMID: 38896226

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