Predictors of adherence and persistence to disease-modifying therapies in Multiple Sclerosis
Zanga, Gisela (Universidad de Buenos Aires)
Drzewiscki, Estefania (Universidad de Buenos Aires)
Tagliani, Paula (Universitat Autònoma de Barcelona)
Smietniansky, Maximiliano (Hospital Italiano de Buenos Aires (Buenos Aires, Argentina))
Esnaola y Rojas, Maria M. (Hospital Italiano de Buenos Aires (Buenos Aires, Argentina))
Caruso, Diego (Hospital Italiano de Buenos Aires (Buenos Aires, Argentina))

Date:	2021
Abstract:	In multiple sclerosis (MS), non-adherence/non-persistence is related to suboptimal response to treatment, including disease relapses and the need for more expensive healthcare. The aim of this study was to identify predictors related to adherence to disease modifying therapies (DMTs) in a cohort of Argentinian MS patients. We conducted a cross-sectional study at the National Medical Care Program from Argentina. MS patients with at least one claim for a DMT from 1 January 2017 to 1 October 2017 were identified. A telephone survey was performed to assess clinical and demographic factors. The medication possession ratio (MPR) was used to estimate adherence; MPR <80% defined non-adherence. Associations were studied using a logistic regression model. Our database included 648 MS patients. A total of 360 patients (60% females, mean age 55. 3 years) accepted to participate. Of these, 308 (85. 5%) patients were receiving DMT at the time of the survey. Some 198 (63. 7%) were receiving injectable therapies. Optimal adherence was 47. 7%. Adherence was associated with oral medication [odds ratio (OR) 1. 83 95% confidence interval (CI) 1. 13-3. 00, p = 0. 014]. A factor related to oral drugs was higher educational level (OR 2. 86 95%CI 1. 41-5. 81, p = 0. 004). This real-world study showed better adherence and persistence on treatment with oral therapies in MS patients in Argentina.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Multiple sclerosis ; Adherence ; Persistence ; Predictors ; Disease-modifying therapies
Published in:	Therapeutic Advances in Neurological Disorders, Vol. 14 (october 2021) , ISSN 1756-2864

DOI: 10.1177/17562864211031099
PMID: 34630632

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