The optimal number of induction chemotherapy cycles in clinically lymph node-positive bladder cancer
von Deimling, Markus (University Medical Center Hamburg-Eppendorf)
Mertens, Laura S. (The Netherlands Cancer Institute (NKI) (Netherlands))
Furrer, Marc (Kantonsspital Olten and Bürgerspital Solothurn)
Li, Roger (H. Lee Moffitt Cancer Center and Research Institute)
Tendijck, Guus A.H. (The Netherlands Cancer Institute (NKI) (Netherlands))
Taylor, Jacob (University of Texas Southwestern)
Crocetto, Felice (University of Naples "Federico II")
Maas, Moritz (University of British Columbia)
Mari, Andrea (Università degli Studi di Firenze)
Pichler, Renate (Medical University of Innsbruck)
Moschini, Marco (Vita-Salute San Raffaele)
Tully, Karl Heinrich (Ruhr-University Bochum)
D'Andrea, David (Medical University of Vienna)
Laukhtina, Ekaterina (Medical University of Vienna)
Del Giudice, Francesco (Università degli Studi di Roma "La Sapienza")
Marcq, Gautier (University of Lille)
Velev, Maud (Université Paris-Saclay)
Gallioli, Andrea (Institut de Recerca Sant Pau)
Albisinni, Simone (Université Libre de Bruxelles)
Mori, Keiichiro (The Jikei University School of Medicine)
Khanna, Abhinav (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Rink, Michael (Marienkrankenhaus)
Fisch, Margit (University Medical Center Hamburg-Eppendorf)
Minervini, Andrea (Università degli Studi di Firenze)
Black, Peter C. (University of British Columbia)
Lotan, Yair (University of Texas Southwestern)
Spiess, Philippe E. (H. Lee Moffitt Cancer Center and Research Institute)
Kiss, Bernhard (University Hospital Bern)
Shariat, Shahrokh (Charles University)
Pradere, Benjamin (La Croix du Sud Hospital (Toulouse, França))
Afferi, Luca
Antonelli, Alessandro
Antonelli, L.
Bacchiani, M.
Bianchi, A.
Flippot, R.
Longoni, M.
Maier, E.
Penel, N.
Sarkis, J.
Soria, Francesco
Woldu, S.
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	To investigate the optimal number of induction chemotherapy cycles needed to achieve a pathological response in patients with clinically lymph node-positive (cN+) bladder cancer (BCa) who received three or four cycles of induction chemotherapy followed by consolidative radical cystectomy (RC) with pelvic lymph node dissection. We included 388 patients who received three or four cycles of cisplatin/gemcitabine or (dose-dense) methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC), followed by consolidative RC for cTanyN1-3M0 BCa. We compared pathological complete (pCR = ypT0N0) and objective response (pOR = yp ≤T1N0) between treatment groups. Predictors of pCR and/or pOR were assessed using uni- and multivariable logistic regression analysis. The secondary endpoints were overall (OS) and cancer-specific survival (CSS). We evaluated the association between the number of induction chemotherapy cycles administered and survival outcomes on multivariable Cox regression. Overall, 101 and 287 patients received three or four cycles of induction chemotherapy, respectively. Of these, 72 (19%) and 128 (33%) achieved pCR and pOR response, respectively. The pCR (20%, 18%) and pOR (40%, 31%) rates did not differ significantly between patients receiving three or four cycles (P.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cn+ ; Induction chemotherapy ; Pathology ; Survival ; Urinary bladder neoplasms
Publicado en:	BJU International, Vol. 134 Núm. 1 (july 2024) , p. 119-127, ISSN 1464-410X

DOI: 10.1111/bju.16319
PMID: 38470089

9 p, 758.9 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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