Cortical Macro- and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
Pardo, Jèssica (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Montal, Victor (Barcelona Supercomputing Center)
Campabadal, Anna (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Oltra, Javier (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Uribe, Carme (Campbell Family Mental Health Research Institute)
Roura, Ignacio (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Martí, Maria J. (Hospital Clínic i Provincial de Barcelona)
Compta, Yaroslau (Hospital Clínic i Provincial de Barcelona)
Iranzo, Alex (Hospital Clínic i Provincial de Barcelona)
Fortea, Juan (Institut de Recerca Sant Pau)
Junqué, Carme (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Segura, Bàrbara (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh). Twenty-two PD-pRBD, 31 PD without probable RBD (PD-nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1-weighted and diffusion-weighted magnetic resonance imaging on a 3-T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two-class group comparisons of a general linear model were performed (P < 0. 05). Cohen's d effect size for both approaches was computed. PD-pRBD patients showed higher cMD than PD-nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule (d > 0. 8), whereas CTh did not detect significant differences. PD-pRBD patients also showed increased bilateral posterior cMD in comparison with HCs (d > 0. 8). These results partially overlapped with CTh results (0. 5 < d < 0. 8). PD-nonpRBD patients showed no differences in cMD when compared with HCs but showed cortical thinning in the left fusiform gyrus and lateral occipital cortex bilaterally (d > 0. 5). cMD may be more sensitive than CTh displaying significant cortico-structural differences between PD subgroups, indicating this imaging biomarker's utility in studying early cortical changes in PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Ayudas:	Agencia Estatal de Investigación PID2020-114640GB-I00 Instituto de Salud Carlos III PI20/01473
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Parkinson's disease ; Cortical mean diffusivity ; Cortical thickness ; Magnetic resonance imaging ; Rapid eye movement sleep behavior disorder
Publicado en:	Movement Disorders, Vol. 39 Núm. 5 (may 2024) , p. 814-824, ISSN 1531-8257

DOI: 10.1002/mds.29761
PMID: 38456361

11 p, 939.7 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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