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| Página principal > Artículos > Artículos publicados > Age-Related Differences in Takotsubo Syndrome : |
(Ruhr University of Bochum) (University of Foggia) (Hospital Clínico San Carlos (Madrid)) (University Heart Center Lübeck) (Madre Giuseppina Vannini Hospital) (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) (University Hospital "Umberto I-Lancisi-Salesi") (University Hospital P. Giaccone) (Università degli Studi di Roma "La Sapienza") (Madre Giuseppina Vannini Hospital) (University of Rome Tor Vergata) (San Paolo Hospital) (San Marco Hospital) (University of Cagliari) (University of Foggia) (Università degli Studi di Roma "La Sapienza") (Complejo Hospitalario Universitario de Albacete) (Universidad Europea. Universidad Complutense) (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) (Institut de Recerca Sant Pau) (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) (Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute) (University of Foggia) (University Heart Center Lübeck) (University of Mannheim) (University Heart Center Lübeck)| Fecha: | 2024 |
| Resumen: | The role of age in the short-and long-term prognosis of takotsubo syndrome (TTS) is controversial. The aim of the present study was to evaluate age-related differences and prognostic implications among patients with TTS. In total, 2492 consecutive patients with TTS enrolled in an international registry were stratified into 4 groups (<45, 45-64, 65-74, and ≥75 years). The median long-term follow-up was 480 days (interquartile range, 83-1510 days). The primary outcome was all-cause mortality (in-hospital and out-of-hospital mortality). The secondary end point was TTS-related in-hospital complications. Among the 2479 patients, 58 (2. 3%) were aged <45 years, 625 (25. 1%) were aged 45 to 64 years, 733 (29. 4%) were aged 65 to 74 years, and 1063 (42. 6%) were aged ≥75 years. Young patients (<45 years) had a higher prevalence of men (from youngest to oldest, 24. 1% versus 12. 6% versus 9. 7% versus 11. 4%; P<0. 01), physical trig-gers (46. 6% versus 27. 5%, 33. 9%, and 38. 4%; P<0. 01), and non-apical forms of TTS (25. 9% versus 23. 7%, 12. 7%, and 9%; P<0. 01) than those aged 45 to 64, 65 to 74, and ≥75 years. During hospitalization, young patients experienced a higher rate of in-hospital complications (32. 8% versus 23. 4%, 27. 4%, and 31. 9%; P=0. 01), but in-hospital mortality was higher in the older group (0%, 1. 6%, 2. 9%, and 5%; P=0. 001). Long-term all-cause mortality was significantly higher in the older cohort (5. 6%, 6. 4%, 11. 3%, and 22. 3%; log-rank P<0. 001), as was long-term cardiovascular mortality (0%, 0. 9%, 1. 9%, and 3. 2%; log-rank P=0. 01). Young patients with TTS have a typical phenotype characterized by a higher prevalence of male sex, non-apical ballooning patterns, and in-hospital complications. However, in-hospital and long-term mortality are significantly lower in young patients with TTS. |
| Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.  |
| Lengua: | Anglès |
| Documento: | Article ; recerca ; Versió publicada |
| Materia: | Age variation ; Short- and long-term outcome ; Takotsubo syndrome |
| Publicado en: | Journal of the American Heart Association. Cardiovascular and cerebrovascular disease, Vol. 13 Núm. 4 (20 2024) , p. e030623, ISSN 2047-9980 |
