Metabolic and Clinical Outcomes in Type 1 Diabetes in the COVID-19 Pre- and Post-Vaccination Periods in Spain : The COVID-SED1 Study
Gómez-Peralta, Fernando (Hospital General de Segovia)
Menéndez Torre, E. (Hospital Universitario Central de Asturias)
Conde, Santiago (Centro de Salud de Barbastro)
Abellán-Galiana, Pablo (Universidad CEU Cardenal Herrera)
Brito, Miguel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Beléndez, Marina (Universidad de Alicante)
Pérez Pérez, Antonio (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	Aims: To evaluate the metabolic and clinical outcomes in the Spanish type 1 diabetes mellitus (T1D) population before and after COVID-19 vaccination. Methods: A retrospective observational study was carried out in Spanish public hospitals previously enrolled in the SED1 study. Adults and children with T1D were included and their clinical electronic records were reviewed. Clinical, laboratory, and glucometric parameters from continuous glucose monitoring (CGM) data corresponding to the periods before and after administering the first COVID-19 vaccination were analyzed. Results: A total of 26 centers and 228 patients participated in this new phase of the SED1 study and 187 were finally evaluable (mean age 37. 5 ± 15. 6 years, 56. 7% women). Overall, 94. 6% of the sample was vaccinated, and this percentage increased with higher levels of education (p-value = 0. 027). In the pre- and post-vaccination periods, respectively, the number of patients with acute hyperglycemic decompensation was 6/161 (3. 7%) and 7/161 (4. 3%) (p = 1) and with acute hypoglycemic decompensation was 6/161 (3. 7%) and 6/161 (3. 7%) (p = 1). The HbA1c level was lower in the post-vaccination period(mean ± SD, mg/dL): pre-vaccination 7. 4 ± 0. 9; post-vaccination 7. 2 ± 1. 0, (-0. 19; p-value = 0. 0006). A total of 31. 9% of patients (95% CI: 24. 7-39. 7) in the pre-vaccination period and 45. 0% (IC95%: 37. 1-53. 1) in the post-vaccine period had HbA1c < 7% (p-value < 0. 001). Glucometrics from CGM data also showed numerical improvements post-vaccination. Conclusions: The COVID-19 vaccination was highly accepted in the Spanish T1D population, with hesitancy about the COVID-19 vaccine being higher in those with lower educational levels. A mildly better glycemic control was observed in the post-vaccination period.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	COVID-19 ; Continuous glucose monitoring ; Diabetes complications ; Glycemic control ; Type 1 diabetes ; Vaccination
Publicado en:	Journal of clinical medicine, Vol. 13 Núm. 7 (april 2024) , p. 1922, ISSN 2077-0383

DOI: 10.3390/jcm13071922
PMID: 38610687

12 p, 258.0 KB

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