Use of different synbiotic strategies to improve gut health in dogs
Montserrat-Malagarriga, Miquel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Castillejos, Lorena (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Salas-Mani, Anna (Affinity Petcare)
Torre, Celina (Affinity Petcare)
Martín Orúe, Susana M (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Fecha:	2024
Resumen:	This study evaluated the effects of two synbiotic strategies on the intestinal microbiota and immune response in Beagle dogs. Twelve dogs were subjected to a crossover design with three diets: a control diet (CON), a diet supplemented with fiber and B. velezensis DSM 15544 (SYN), and the SYN diet with added porcine plasma (SYN+). Over three periods of seven weeks, fecal samples were analyzed for digestibility, short-chain fatty acids (SCFA), fecal markers, and microbiome composition, while blood samples were assessed for biochemical parameters, leucocytic counts including CD4/CD8 lymphocyte populations, and phagocytic activity. Both SYN and SYN+ diets increased the fecal volume without affecting the consistency and slightly reduced the organic matter and energy digestibility, while increasing SCFA concentrations and reducing branched-chain fatty acids. A microbiome analysis revealed no changes in the alpha diversity, but significant shifts in the beta diversity, with increases in beneficial taxa such as Faecalibacterium prausnitzii and reductions in potentially harmful bacteria like Prevotella copri. Immune response indicators showed increased fecal IgA and higher blood leukocyte counts, particularly lymphocytes and neutrophils, in the SYN diet group. Overall, both synbiotic strategies positively modulated the microbiota and immune response, though the addition of porcine plasma did not confer additional benefits.
Nota:	Altres ajuts: funded by Affinity Pet Care SA, UAB research agreement CF618022; M.M.-M. received a PhD grant from the European Social Fund in collaboration with the Generalitat de Catalunya, grant 2020 FI-B 00366.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Dietary fiber ; Dog ; Dried plasma ; Immunity ; Microbiota ; Prebiotic ; Probiotic ; Synbiotic
Publicado en:	Animals, Vol. 14 Núm. 23 (2024) , p. 3366, ISSN 2076-2615

DOI: 10.3390/ani14233366
PMID: 39682332

19 p, 2.2 MB

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