Electrical conductivity measurement in human liver tissue : assessment on normal vs. tumor tissue and under in vivo vs. ex vivo conditions
Sarreshtehdari, Amirhossein (Universitat Pompeu Fabra)
García-Sánchez, Tomás (Universitat Pompeu Fabra)
Sánchez-Velázquez, Patricia (Universitat Pompeu Fabra)
Ielpo, Benedetto (Universitat Pompeu Fabra)
Berjano, Enrique (Universitat Politècnica de València)
Villamonte, Maria (Universitat Pompeu Fabra)
Moll, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Burdío, Fernando (Universitat Pompeu Fabra)

Date:	2024
Abstract:	Background: This study evaluated electrical conductivity in human liver tissue in the 3-1000 kHz frequency range to compare normal versus tumor tissues under in vivo versus ex vivo conditions. Methods: Previous informed consent was obtained from twenty patients undergoing liver resection in whom liver electrical conductivity was measured during surgery and after resection. Result: We found higher electrical conductivity values in tumor tissues than in normal tissue in both in vivo (0. 41 ± 0. 10 vs. 0. 13 ± 0. 06 S/m) and ex vivo (0. 27 ± 0. 09 vs. 0. 12 ± 0. 07 S/m) conditions (at 3 kHz). The electric properties also showed a promising potential for distinguishing between different tissue types including metastasis, cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatic cirrhosis, and normal liver (both in vivo and ex vivo). At 3 kHz, in vivo electrical conductivity for cholangiocarcinoma, HCC, and metastasis were 0. 35, 0. 42 ± 0. 13, and 0. 41 ± 0. 08 S/m, respectively, which differed significantly from each other (p < 0. 05). Conclusions: These findings could potentially improve liver disease diagnostics through electrical conductivity measurements and treatment techniques involving electric fields. Future research should focus on expanding the sample size to refine the categorization and comparison processes across diverse human liver tissue types.
Grants:	Agencia Estatal de Investigación PID2022-136273OB-C31 Agencia Estatal de Investigación PID2022-136273OB-C32
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Electrical conductivity ; Ex vivo ; Human liver ; In vivo ; Tumor ; SDG 3 - Good Health and Well-being
Published in:	Biosensors, Vol. 14 Núm. 8 (2024) , p. 382, ISSN 2079-6374

DOI: 10.3390/bios14080382
PMID: 39194611

13 p, 1.9 MB

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