Women's neuroplasticity during gestation, childbirth and postpartum
Paternina-Die, María (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Martínez-García, Magdalena (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Martín de Blas, Daniel (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Noguero, Inés (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Servin-Barthet, Camila (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Pretus, Clara (Institut Hospital del Mar d'Investigacions Mèdiques)
Soler, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
López-Montoya, Gonzalo (Universidad Internacional de La Rioja)
Desco, Manuel (Universidad Carlos III de Madrid)
Carmona Cañabate, Susana (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))

Fecha:	2024
Resumen:	Pregnancy is a unique neuroplastic period in adult life. This longitudinal study tracked brain cortical changes during the peripartum period and explored how the type of childbirth affects these changes. We collected neuroanatomic, obstetric and neuropsychological data from 110 first-time mothers during late pregnancy and early postpartum, as well as from 34 nulliparous women evaluated at similar time points. During late pregnancy, mothers showed lower cortical volume than controls across all functional networks. These cortical differences attenuated in the early postpartum session. Default mode and frontoparietal networks showed below-expected volume increases during peripartum, suggesting that their reductions may persist longer. Results also pointed to different cortical trajectories in mothers who delivered by scheduled C-section. The main findings were replicated in an independent sample of 29 mothers and 24 nulliparous women. These data suggest a dynamic trajectory of cortical decreases during pregnancy that attenuates in the postpartum period, at a different rate depending on the brain network and childbirth type. This longitudinal study tracked the brains of 139 first-time mothers. Mothers showed lower cortical volume before childbirth that attenuated during the postpartum, with a distinct recovery rate as a function of the brain network and birth type.
Ayudas:	Instituto de Salud Carlos III PI22/01365 Instituto de Salud Carlos III FI18/00255 "la Caixa" Foundation LCF/PR/HR19/52160001 European Commission 883069
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cognitive neuroscience ; Social neuroscience ; Brain
Publicado en:	Nature Neuroscience, Vol. 27 (january 2024) , p. 319-327, ISSN 1546-1726

DOI: 10.1038/s41593-023-01513-2
PMID: 38182834

18 p, 5.7 MB

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