Insight into synthesis and characterisation of GaFeO superparamagnetic NPs for biomedical applications
Mesaros, Amalia (Technical University of Cluj-Napoca)
Garzón-Manjón, Alba (Institut Català de Nanociència i Nanotecnologia)
Nasui, Mircea (Technical University of Cluj-Napoca)
Bortnic, Rares (Technical University of Cluj-Napoca)
Vasile, Bogdan (National University for Science and Technology Politehnica Bucharest)
Vasile, Otilia (National University for Science and Technology Politehnica Bucharest)
Iordache, Florin (University of Agronomical Sciences and Veterinary Medicine)
Leostean, Cristian (National Institute for Research and Development of Isotopic and Molecular Technologies)
Ciontea, Lelia (Technical University of Cluj-Napoca)
Ros i Badosa, Josep (Universitat Autònoma de Barcelona. Departament de Química)
Pana, Ovidiu (National Institute for Research and Development of Isotopic and Molecular Technologies)

Data:	2023
Resum:	A Ga 3+ -substituted spinel magnetite nanoparticles (NPs) with the formula GaFeO were synthesized using both the one-pot solvothermal decomposition method (TD) and the microwave-assisted heating method (MW). Stable colloidal solutions were obtained by using triethylene glycol, which served as a NPs stabilizer and as a reaction medium in both methods. A narrow size distribution of NPs, below 10 nm, was achieved through selected nucleation and growth. The composition, structure, morphology, and magnetic properties of the NPs were investigated using FTIR spectroscopy, thermal analysis (TA), X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and magnetic measurements. NPs with the expected spinel structure were obtained in the case of the TD method, while the MW method produced, additionally, an important amount of gallium suboxide. The NPs, especially those prepared by TD, have superparamagnetic behavior with 2. 02 μB/f. u. at 300 K and 3. 06 μB/f. u. at 4. 2 K. For the MW sample these values are 0. 5 μB/f. u. and 0. 6 μB/f. u. at 300 K and 4. 2 K, respectively. The MW prepared sample contains a secondary phase and very small NPs which affects both the dimensional distribution and the magnetic behavior of NPs. The NPs were tested in vitro on amniotic mesenchymal stem cells. It was shown that the cellular metabolism is active in the presence of GaFeO NPs and preserves an active biocompatible cytoskeleton.
Ajuts:	European Commission 280432
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Materials science ; Nanoscience and technology
Publicat a:	Scientific reports, Vol. 13 (October 2023) , art. 18175, ISSN 2045-2322

DOI: 10.1038/s41598-023-45285-y
PMID: 37875541

15 p, 2.7 MB

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