Identification of Antimicrobial-Resistant Zoonotic Bacteria in Swine Production : Implications from the One Health Perspective
Ventero, Maria Paz (Instituto de Investigación Sanitaria y Biomédica de Alicante)
Marín Orenga, Clara (Universidad CEU Cardenal Herrera)
Migura-Garcia, Lourdes (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Tort-Miró, Carla (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Giler-Baquerizo, Noemí (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Gomez, Inmaculada (Instituto de Investigación Sanitaria y Biomédica de Alicante)
Escribano, Isabel (Instituto de Investigación Sanitaria y Biomédica de Alicante)
Marco-Fuertes, Ana (Universidad CEU Cardenal Herrera)
Montoro-Dasi, Laura (Universidad CEU Cardenal Herrera)
Lorenzo-Rebenaque, Laura (Universitat Politècnica de València)
Vega, Santiago (Universidad CEU Cardenal Herrera)
Pérez-Gracia, Maria Teresa (Universidad CEU Cardenal Herrera)
Rodríguez, Juan Carlos (Universidad Miguel Hernández de Elche)

Fecha:	2024
Resumen:	Antimicrobial resistance poses a major threat to global health and food security and is primarily driven by antimicrobial use in human and veterinary medicine. Understanding its epidemiology at farm level is crucial for effective control measures. Despite the significant reduction in antibiotic use in conventional livestock production, the swine sector traditionally has a higher level of antibiotic use in veterinary medicine. Consequently, multidrug resistance (MDR) among microbial isolates of swine origin has been relatively frequent. The aim of this study was to assess the presence of multidrug-resistant (MDR) bacteria, enteric pathogens and resistance genes to the main antibiotics used in clinical practice, both within the environment and in animals across pig farms characterized by varying degrees of sanitary status. A total of 274 samples were collected. Of these, 34 samples were collected from the environment (wall swabs, slat swabs and slurry pit), and 240 samples were collected from animals (sows' and piglets' rectal faeces). All samples were analysed for MDR bacteria and enteric pathogens. The study revealed a high frequency of extended-spectrum beta-lactamases (ESBL)-producing Enterobacterales and Campylobacter spp. , with ESBL-producing Enterobacterales predominating in high health status farms (environment and animals) and Campylobacter spp. in both high health status and low health status environments. Additionally, a high percentage of methicillin-resistant Staphylococcus aureus (MRSA) was found, mainly in environmental samples from high health status farms, and Clostridioides difficile was distributed ubiquitously among farms and samples. Furthermore, though less frequently, vancomycin-resistant Enterococcus faecium (VRE) was isolated only in high health status farms, and Gram-negative bacilli resistant to carbapenems were isolated only in environmental samples of high health status and low health status farms. This study underscores the importance of surveillance for MDR bacteria in farm animals and their environment, including their waste. Such ecosystems serve as crucial reservoirs of bacteria, requiring national-level surveillance to promote responsible antibiotic use and pandemic control.
Ayudas:	Agencia Estatal de Investigación PID2021-125641OB-C22 Agencia Estatal de Investigación PID2021-125641OB-C21 Agencia Estatal de Investigación PTA2021-020215-I
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Global health ; Pig farms ; Multidrug resistant microorganism
Publicado en:	Antibiotics, Vol. 13 (september 2024) , ISSN 2079-6382

DOI: 10.3390/antibiotics13090883
PMID: 39335056

13 p, 1.3 MB

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