The Personal Glucose Meter as the Measurement Principle in Point-of-Care Applications
Cano, Mònica (Universitat Autònoma de Barcelona. Departament de Química)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)

Fecha:	2025
Resumen:	A personal glucose meter (PGM) is a medical device that measures blood glucose levels and can be found worldwide. Owing to their sensitivity, simplicity, portability, and low cost, PGMs stand as one of the most frequently utilized analytical methods. This work reviews the different applied methodologies for detecting analytes other than glucose employing a PGM and how it can be incorporated for point-of-care diagnosis needs. To visualize the variants, first, a classification is made according to the biorecognition elements used (aptamers, antibodies, etc. ), and where the determination of different analytes is done through the glucose signal using different glucose-generating enzymes such as invertase or glucosidase. Transduction can also be based on the use of nanocarriers that generally encapsulate glucose, although it is also possible to find a combination of the two aforementioned strategies. The PGM can also be used for the direct detection of interfering substances of the biosensor, such as NADH or paracetamol. Lastly, we discuss how a PGM might have been implemented to detect COVID-19 and how it could be used on a massive scale for the point-of-care diagnosis of a pandemic.
Ayudas:	Agencia Estatal de Investigación PID2022-136709OB-C21 Agencia Estatal de Investigación RED2022-134120-T Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00124
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article de revisió ; recerca ; Versió publicada
Materia:	Glucose biosensor ; Point-of-care ; Aptamer ; Antibody ; Invertase enzyme label
Publicado en:	Biosensors, Vol. 15, Issue 2 (February 2025) , art. 121, ISSN 2079-6374

DOI: 10.3390/bios15020121
PMID: 39997023

20 p, 8.0 MB

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