Intratumoural tigilanol tiglate in the multicentre treatment of equine sarcoids and cutaneous melanomas
Labens, Raphael (Charles Sturt University)
Saba, Corey (University of Georgia)
Williams, Jarred (University of Georgia)
Hollis, Anna (University of Cambridge)
Ensink, Jos (Utrecht University)
José Cunilleras, Eduard (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Jordana Garcia, Mireia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Bergvall, Kerstin (Swedish University of Agricultural Sciences)
Ruppin, Mick (Tableland Veterinary Service)
Condon, Frank (Tableland Veterinary Service)
Spelta, Caroline (APIAM Animal Health)
Elce, Yvonne (University Prince Edward Island)
De Ridder, Thomas (QBiotics Group)
Morton, John (Jemora Consulting)
McGee, Cassandra (QBiotics Group)
Reddell, Paul (QBiotics Group)

Publicació:	Wiley-Blackwell, 2025
Resum:	BACKGROUND: Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol-tiglate (TT), a novel molecule extracted from Fontainea picrosperma, an Australian rainforest plant, is registered for intratumoural treatment of canine MCT, leading to rapid oncosis and tumour slough. Evidence from horses is limited but suggests that efficacy may be similar. OBJECTIVES: To evaluate the response to intratumoural TT treatment in horses with sarcoids (fibroblastic/nodular) and cutaneous melanomas. STUDY DESIGN: Two noncontrolled prospective multicentre clinical trials, one for each of sarcoids and melanomas. METHODS: Cases were enrolled across multiple sites and treated by the same site-specific clinician with intralesional TT (sarcoids: 0. 35 mg/cm3; melanomas: 0. 2 mg/cm3 of tumour volume - Tvol; max dose 2 mg). Quantitative (Tvol regression) and qualitative outcomes (likely tumour free (LTF) per expert opinion) were recorded, and potential determinants of efficacy were assessed using random effects logistic models. A full clinical response was complete Tvol regression and a LTF treatment site. RESULTS: Forty-one sarcoids and 97 melanomas were enrolled and treated. 73/74% of treated sarcoids/melanomas showed complete Tvol regression. 64/61% (sarcoids/melanomas) showed a full clinical response at medians of 546/247 days post final treatment. For both tumour types, this response was dependent on initial tumour volume (Psarcoids = 0. 006; Pmelanomas <0. 001). The predicted probability of a full clinical response was 6 times greater for initially small sarcoids (Tvol = 1 cm3) than for the maximum study volume (Tvol = 6 cm3). For melanomas in the perineal region, this was 11 times greater for Tvol ≤0. 3 cm3 than for tumours ≥2. 0 cm3. For melanomas, tumour location further affected treatment efficacy = 0. 005). In total, 5 adverse events were reported. MAIN LIMITATIONS: Lack of treatment control and histologic/biomolecular follow-up data. CONCLUSIONS: The observed therapeutic efficacy of TT supports clinical use as well as early interventions in horses. Successful use necessitates knowledge of the drug's mode of action and management of associated local site responses.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Horse ; Neoplasia ; Skin ; Stelfonta
Publicat a:	Equine Veterinary Journal, ISSN 2042-3306

DOI: 10.1111/evj.14502
PMID: 40170619

16 p, 2.2 MB

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