C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration
Giralt, Lena (Universidad del País Vasco. Departamento de Oftalmología)
Figueras-Roca, Marc (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Eguileor, Beatriz De Luis (Universidad del País Vasco. Departamento de Oftalmología)
Romero, Barbara (Institut Clínic d'Oftalmologia)
Zarranz-Ventura, Javier (Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer)
Alforja, Socorro (Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer)
Santiago, Francisca (Hospital Clínic i Provincial de Barcelona)
Bolaños, Jennifer (Hospital Clínic i Provincial de Barcelona)
Lozano, Francisco (Universitat de Barcelona. Departament de Biomedicina)
Dotti-Boada, Marina (Institut Clínic d'Oftalmologia)
Sala-Puigdollers, Anna (Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer)
Dura, Paula (Universidad del País Vasco. Departamento de Oftalmología)
Izquierdo-Serra, Jordi (Institut Clínic d'Oftalmologia)
Valero, Oliver (Universitat Autònoma de Barcelona. Servei d'Estadística Aplicada (SEA))
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer)
Fonollosa, Alex (Instituto Oftalmológico Bilbao)
Molins, Blanca (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Data:	2024
Resum:	To determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters. Cross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters. Patients with intermediate AMD presented FH levels significantly lower than controls [186. 5 (72. 1-931. 8) µg/mL vs 415. 2 (106. 1-1962. 2) µg/mL; p=0. 039] and FH levels <200 µg/mL were associated with the presence of drusen and pigmentary changes in the fundoscopy (p=0. 002). While no differences were observed in pCRP and mCRP levels, and mCRP was only detected in less than 15% of the included participants, women had a significantly higher detection rate of mCRP than men (21. 0% vs. 3. 8%, p=0. 045). In addition, the ratio mCRP/FH (log) was significantly lower in the control group compared to intermediate AMD (p=0. 031). Visual acuity (p<0. 001), macular volume (p<0. 001), and foveal thickness (p=0. 034) were significantly lower in the advanced AMD group, and choroidal thickness was significantly lower in advanced AMD compared to early/intermediate AMD (p=0. 023). Intermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients.
Ajuts:	Instituto de Salud Carlos III PI19/00265
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Age-related macular degeneration ; Inflammation ; Complement factor H ; C-reactive protein ; Retina ; Biomarker
Publicat a:	Frontiers in immunology, Vol. 15 (April 2024) , art. 1330913, ISSN 1664-3224

DOI: 10.3389/fimmu.2024.1330913
PMID: 38633250

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