High-risk cytogenetic abnormalities in multiple myeloma : PETHEMA-GEM experience
González-Calle, Verónica (Hospital Universitario de Salamanca (Castella i LLeó))
Rodriguez-Otero, Paula (Clínica Universidad de Navarra. Cancer Center)
Calasanz, M.J. (Clínica Universidad de Navarra. Cancer Center)
Guijarro, Manuela (Hospital 12 de Octubre (Madrid))
Martínez-López, Joaquín (Hospital 12 de Octubre (Madrid))
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona)
Hernández, Miguel Teodoro (Hospital Universitario de Canarias (La Laguna))
Teruel, Ana I. (Hospital Clínic Universitari (València))
Gironella, Mercedes (Hospital Universitari Vall d'Hebron)
Oriol, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
de la Rubia, Javier (Hospital Universitari i Politècnic La Fe (València))
Gonzalez-Rodriguez, Ana Pilar (Hospital Universitario Central de Asturias)
Bargay, Joan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
De Arriba, Felipe (Hospital General Universitario Morales Meseguer (Múrcia))
Palomera, Luis (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
González-Pérez, Marta Sonia (Complejo Hospitalario Universitario de Santiago de Compostela)
Sureda, Anna (Institut Català d'Oncologia)
Ocio, Enrique (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Lahuerta, J. J. (Hospital 12 de Octubre (Madrid))
Bladé Creixenti, Juan (Hospital Clínic i Provincial de Barcelona)
San Miguel, Jesús F. (Clínica Universidad de Navarra. Cancer Center)
Mateos, M. V. (Instituto de Investigación Biomédica de Salamanca (Castella i Lleó))
Gutierrez, Norma (Hospital Universitario de Salamanca (Castella i Lleó))
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	This study examines the impact of cytogenetic abnormalities and their co-segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four different GEM-PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. The frequency of genetic alterations detected were as follows: del(17p) in 8%, t(4;14) in 12%, t(14;16) in 3%, +1q in 43%, and del(1p) in 8%. The median follow-up was 61 months, and the median progression-free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. Consistent with previous reports, the presence of t(4;14) was associated with shorter PFS and OS. In our series, the presence of t(14;16) did not impact survival, maybe due to limitations in sample size. Del(17p) was linked to poor prognosis using a cut-off level of ≥20% positive cells, without any impact of higher cut-off in prognosis, except for patients with clonal fraction ≥80% who had a dismal outcome. Cosegregation of cytogenetic abnormalities patients worsened the prognosis in t(4;14) patients but not in patients with del(17p), which retained its adverse prognosis even as a solitary abnormality. Gain(1q) was associated with significantly shorter PFS and OS, while del(1p) affected PFS but not OS. Nevertheless, when co-segregation was eliminated, the detrimental effect of +1q or del(1p) was no longer observed. In conclusion, this study confirms the prognostic significance of high-risk cytogenetic abnormalities in MM and highlights the importance of considering co-occurrence for accurate prognosis assessment.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	HemaSphere, Vol. 8 Núm. 12 (december 2024) , p. e70031, ISSN 2572-9241

DOI: 10.1002/hem3.70031
PMID: 39665068

11 p, 1.7 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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