Antibiotic desensitization as a potential tool in antimicrobial stewardship programs : retrospective data analysis and systematic literature review
Rodríguez-Alarcón, Alicia (Universitat Autònoma de Barcelona)
Barceló-Vidal, Jaime (Institut Hospital del Mar d'Investigacions Mèdiques)
Echeverría-Esnal, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques)
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques)
Güerri-Fernández, Robert (Institut Hospital del Mar d'Investigacions Mèdiques)
Ramis Fernández, Sofía Martina (Institut Hospital del Mar d'Investigacions Mèdiques)
Benítez-Cano, Adela (Institut Hospital del Mar d'Investigacions Mèdiques)
Sendra, Elena (Institut Hospital del Mar d'Investigacions Mèdiques)
López Montesinos, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques)
Membrilla Fernández, Estela (Institut Hospital del Mar d'Investigacions Mèdiques)
Ferrández, Olivia (Institut Hospital del Mar d'Investigacions Mèdiques)
Adàlia, Ramon (Institut Hospital del Mar d'Investigacions Mèdiques)
Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques)
Escolano Villen, Fernando (Institut Hospital del Mar d'Investigacions Mèdiques)
Gómez-Zorrilla, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques)
Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques)

Fecha:	2022
Resumen:	Objectives: Antibiotic allergy labels (AAL) are related to worse therapeutic results. Strategies to improve the management of these patients, such as the implementation of antibiotic desensitization, are essential for Antimicrobial Stewardship Programs (ASP). The aim of our study is to evaluate the efficacy and safety of antibiotic desensitization procedures for the management of patients with AAL. Methods: A retrospective study from 2015 to 2022 was performed to describe all antibiotic desensitization conducted in our institution, within the framework of ASP. A systematic literature review using electronic databases, such as PubMed, was also done to identify studies describing antibiotic desensitization between 2000 and 2022. Results: Sixteen antibiotic desensitization protocols were carried out in our institution. In fourteen cases, the desensitization was successfully completed, and the antibiotic could be used to treat the infection. In the systematic review, twenty-two studies were included, with a total of 202 desensitization episodes. In 97% of them, the desensitization was completed successfully. No desensitization-related mortality was observed neither in our cohort nor in literature review. Conclusions: Antibiotic desensitization strategies should be considered a safe and effective tool that can be included in ASP for patients with a high risk of or confirmed allergy to penicillin.
Ayudas:	Instituto de Salud Carlos III PI21/00509
Derechos:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Anti-bacterial agents ; Antimicrobial stewardship programs ; Desensitization ; Hypersensitivity ; Immunologic ; Penicillins
Publicado en:	Expert Review of Anti-Infective Therapy, Vol. 20, Núm. 11 (November 2022) , p. 1491-1500, ISSN 1744-8336

DOI: 10.1080/14787210.2022.2122443

Postprint 22 p, 324.9 KB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados