Switching from risperidone to paliperidone palmitate in schizophrenia : Changes in social functioning and cognitive performance
Tost, Meritxell (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
González-Rodríguez, Alexandre (Universitat de Barcelona. Hospital Mútua de Terrassa)
Aguayo, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Àlvarez, Aida (Universitat de Barcelona. Hospital Mútua de Terrassa)
Montalvo, Itziar (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Barbero, Juan David (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gabernet, Rosa (Hospital de Mataró. Consorci Sanitari del Maresme)
Izquierdo, Eduard (Universitat de Barcelona. Hospital Mútua de Terrassa)
Merodio Ruiz, Igor (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Monreal Ortiz, Jose Antonio (Universitat de Barcelona. Hospital Mútua de Terrassa)
Palao, Diego (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Labad, Javier (Hospital de Mataró. Consorci Sanitari del Maresme)

Fecha:	2023
Resumen:	Background: Previous studies suggest that paliperidone might show a better profile for social functioning and cognitive abilities than risperidone. We aimed to study whether switching from risperidone to paliperidone palmitate (PP) is associated with improved cognitive abilities at 3 or 6 months after the switch. Methods: Thirty-eight patients with a DSM-IV diagnosis of schizophrenia were studied. All patients were treated with oral risperidone or risperidone long-acting injection (RLAI) and had an indication to be switched to PP by their psychiatrists. Statistical analyses were conducted in a final sample of 27 patients who completed the follow-up visits. Three assessments were completed: 1) baseline (preswitch), 2) 3 months postswitch, and 3) 6 months postswitch. Social functioning at each visit was assessed with the Personal and Social Performance Scale. Cognitive assessment was conducted at each visit with the MATRICS Consensus Cognitive Battery. Statistical analyses were performed with R. Linear mixed models were used to explore longitudinal changes in social functioning and cognitive outcomes. Results: PSP scores significantly improved over time after the switch from risperidone to PP. A sensitivity analysis found a significant negative interaction between time and PP maintenance doses (greater improvement in those patients receiving lower doses when compared to higher doses). Regarding longitudinal changes in cognitive functioning, patients improved in 6 out of 10 cognitive tasks involving processing speed, working memory, visual memory, reasoning and problem solving, and attention and vigilance. Conclusions: Our study suggests that switching from risperidone to PP in patients with schizophrenia is associated with an improvement in social functioning and cognitive performance.
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Lengua:	Anglès
Documento:	Article ; recerca ; Versió acceptada per publicar
Materia:	Cognition ; Paliperidone ; Risperidone ; Schizophrenia ; Social functioning
Publicado en:	Progress in neuro-psychopharmacology & biological psychiatry, Vol. 120 (January 2023) , ISSN 1878-4216

DOI: 10.1016/j.pnpbp.2022.110619

Postprint 36 p, 664.8 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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