Into the metabolic wild : Unveiling hidden pathways of microbial metabolism
Ata, Özge (BOKU University. Institute of Microbiology and Microbial Biotechnology)
Mattanovich, Diethard (BOKU University. Institute of Microbiology and Microbial Biotechnology)

Fecha:	2024
Resumen:	Microbial metabolism has been deeply studied over decades and it is considered to be understood to a great extent. Annotated genome sequences of many microbial species have contributed a lot to generating biochemical knowledge on metabolism. However, researchers still discover novel pathways, unforeseen reactions or unexpected metabolites which contradict to the expected canon of biochemical reactions in living organisms. Here, we highlight a few examples of such non-canonical pathways, how they were found, and what their importance in microbial biotechnology may be. The predictive power of metabolic modelling, well-founded on biochemical knowledge and genomic information is discussed in the light of both discovery of yet unknown existing metabolic routes and the prediction of others, new to Nature.
Ayudas:	European Commission 101000441
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Microbial biotechnology, Vol. 17, Issue 8 (August 2024) , art. e14548, ISSN 1751-7915

DOI: 10.1111/1751-7915.14548
PMID: 39126421

7 p, 863.0 KB

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