Effectiveness of the BNT162b2 XBB.1.5-adapted vaccine against COVID-19 hospitalization related to the JN.1 variant in Europe : a test-negative case-control study using the id.DRIVE platform
Nguyen, Jennifer L. (Pfizer Inc)
Mitratza, Marianna (P95 Epidemiology and Pharmacovigilance)
Volkman, Hannah R. (Pfizer Inc)
de Munter, Leonie (P95 Epidemiology and Pharmacovigilance)
Tran, Thao Mai Phuong (P95 Epidemiology and Pharmacovigilance)
Marques, Catia (Pfizer Inc)
Mustapha, Mustapha (Pfizer Inc)
Valluri, Srinivas (Pfizer Inc)
Yang, Jingyan (Pfizer Inc)
Antón Pagarolas, Andrés, 1976- 1976- (Vall d'Hebron Institut de Recerca (VHIR))
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Conde-Sousa, Eduardo (P95 Epidemiology and Pharmacovigilance)
Drikite, Laura (P95 Epidemiology and Pharmacovigilance)
Grüner, Beate (University Hospital of Ulm (Alemanya))
Icardi, Giancarlo (Centro Interuniversitario per la Ricerca sull'Influenza e le altre Infezioni Trasmissibili - IRCCS Policlinico San Martino Hospital)
ten Kate, Gerrit Luit (Universitair Ziekenhuis Antwerpen)
Martin, Charlotte (Le Centre Hospitalier Universitaire St Pierre)
Mira Iglesias, Ainara (Instituto de Salud Carlos III)
Orrico Sánchez, Alejandro (Instituto de Salud Carlos III)
Otero-Romero, Susana (Vall d'Hebron Institut de Recerca (VHIR))
Rohde, Gernot (Goethe University Frankfurt)
Jodar, Luis (Pfizer Inc)
McLaughlin, John M. (Pfizer Inc)
Bollaerts, Kaatje (P95 Epidemiology and Pharmacovigilance)
Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

Date:	2024
Abstract:	Prior studies have reported lower effectiveness of XBB. 1. 5-adapted vaccines against hospitalization related to the Omicron JN. 1 variant than the XBB variant. This study evaluated the effectiveness and durability of the BNT162b2 XBB. 1. 5-adapted vaccine against JN. 1-related hospitalization during the 2023-2024 season in Europe. A test-negative case-control study was carried out in adults (≥18 y) hospitalized between 2 October 2023 and 2 April 2024 with severe acute respiratory infection (SARI) within the id. DRIVE partnership. This study included nine sites across Belgium, Germany, Italy, and Spain. Cases had a laboratory-confirmed JN. 1 infection or a positive SARS-CoV-2 test with symptom onset during JN. 1 predominance; controls had a negative SARS-CoV-2 test and symptom onset during JN. 1 predominance. The primary objective was to estimate BNT162b2 XBB. 1. 5-adapted vaccine effectiveness (VE) against COVID-19 hospitalization. One case was matched with up to four controls, according to symptom onset date and site. Multivariable analyses were adjusted for symptom onset date, age, sex, and number of chronic conditions. Among 308 test-positive cases and 1117 test-negative controls, BNT162b2 XBB. 1. 5-adapted VE against hospitalization compared to no vaccination this season was 53. 8% (95% CI 38. 4-65. 4) after a median of 63 days following vaccination. Protection was sustained through five months; VE was 52. 2% (95% CI 41. 3-61. 1) 2 to <4 weeks after vaccination, 48. 9% (95% CI 17. 9-68. 2) at 4 to <8 weeks, and ranged from 54. 6% to 59. 5% at 4-week intervals from 8 to <22 weeks. BNT162b2 XBB. 1. 5-adapted vaccine provided protection against JN. 1-related hospitalization, regardless of prior vaccination history, with no evidence of waning through five months. These data support yearly vaccination against COVID-19 to prevent severe illness during the respiratory virus season.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; SARS-CoV-2 ; COVID-19 vaccination ; Vaccine effectiveness ; BNT162b2 ; XBB adapted vaccine ; JN.1
Published in:	EClinicalMedicine, Vol. 79 (December 2024) , ISSN 2589-5370

DOI: 10.1016/j.eclinm.2024.102995
PMID: 39726669

12 p, 878.9 KB

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