Inflammation : The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications
Ramos, Hugo (Hospital Universitari Vall d'Hebron)
Hernández, Cristina (Hospital Universitari Vall d'Hebron)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Simó-Servat, Olga (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The etiology of diabetic retinopathy (DR) is complex, multifactorial and compromises all the elements of the retinal neurovascular unit (NVU). This diabetic complication has a chronic low-grade inflammatory component involving multiple inflammatory mediators and adhesion molecules. The diabetic milieu promotes reactive gliosis, pro-inflammatory cytokine production and leukocyte recruitment, which contribute to the disruption of the blood retinal barrier. The understanding and the continuous research of the mechanisms behind the strong inflammatory component of the disease allows the design of new therapeutic strategies to address this unmet medical need. In this context, the aim of this review article is to recapitulate the latest research on the role of inflammation in DR and to discuss the efficacy of currently administered anti-inflammatory treatments and those still under development.
Grants:	Instituto de Salud Carlos III ICI20/00129 Instituto de Salud Carlos III PI22/01670 Agència de Gestió d'Ajuts Universitaris i de Recerca BES-2017-081690
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Diabetes ; Diabetic retinopathy ; Retina ; Neurovascular unit ; Inflammation ; Cytokine
Published in:	International journal of molecular sciences, Vol. 24 (may 2023) , ISSN 1422-0067

DOI: 10.3390/ijms24108796
PMID: 37240138

17 p, 1.1 MB

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