Cytocompatibility and antimicrobial properties of silver nanoparticle-decorated hydroxyapatite-coated TiMoNbTa alloy
Escobar, Michael (Universitat Autònoma de Barcelona. Departament de Física)
Turner, Adam Benedict (University of Gothenburg. Department of Biomaterials)
Sort Viñas, Jordi (Universitat Autònoma de Barcelona. Departament de Física)
Nogués, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Pellicer Vilà, Eva Maria (Universitat Autònoma de Barcelona. Departament de Física)
Blanquer Jerez, Andreu (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Trobos, Margarita (University of Gothenburg. Department of Biomaterials)

Date:	2025
Abstract:	Titanium and its alloys are widely used for implants, although they have limitations like higher elastic modulus compared to bone, causing stress shielding and potential implant failure. To address these issues, β-Ti alloys and calcium phosphate coatings are being developed to improve the mechanical properties while enhancing bone integration. The risk of infection is another important limitation that can be addressed through the deposition of antibacterial and antibiofilm coatings on the alloys. Here, we present a β-Ti alloy (Ti-18Mo-6Nb-5Ta (wt %)) coated with calcium-deficient hydroxyapatite (CDHA) and decorated with silver nanoparticles intended to be used as antimicrobial orthopedic implants. The experiments revealed that human osteoblasts were able to adhere and proliferate on coating. The presence of silver nanoparticles did not adversely affect human osteoblast differentiation and led to a 50 % increase in type I collagen production. The coating decorated with silver nanoparticles exhibited a significant antibacterial effect against Staphylococcus aureus, reducing biofilm formation by over 40 % after 24 h compared to the undecorated coating. Taken together, these results show the effectiveness of the silver decorated CDHA coating in enhancing osteoblasts proliferation and differentiation while also reducing biofilm growth when compared to CDHA coating.
Grants:	European Commission 861046 Agencia Estatal de Investigación PID2020-116844RB-C21 Agencia Estatal de Investigación PID2023-148047OA-C22 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00651 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00122
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	В-titanium alloys ; Silver nanoparticles ; Cytocompatibility ; Human osteoblasts ; Antibacterial activity ; Staphylococcus aureus
Published in:	Surfaces and interfaces, Vol. 72 (September 2025) , art. 106934, ISSN 2468-0230

DOI: 10.1016/j.surfin.2025.106934

12 p, 14.8 MB

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